HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity - Wikidata - awgldk - TriplyDB

HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity

HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity

http://www.wikidata.org/entity/Q34775607

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Experimental models of hepatotoxicity related to acute liver failure Acetaminophen-induced Liver Injury: from Animal Models to Humans Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity Pathogenesis of idiosyncratic drug-induced liver injury and clinical perspectives.Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: Application to acetaminophen Dual role of acetaminophen in promoting hepatoma cell apoptosis and kidney fibroblast proliferation.The Impact of Sterile Inflammation in Acute Liver Injury.Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology.Acetaminophen and NAPQI are toxic to auditory cells via oxidative and endoplasmic reticulum stress-dependent pathways.High-throughput and combinatorial gene expression on a chip for metabolism-induced toxicology screening.Mechanisms of acetaminophen-induced cell death in primary human hepatocytes.Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line.Tolerance to acetaminophen hepatotoxicity in the mouse model of autoprotection is associated with induction of flavin-containing monooxygenase-3 (FMO3) in hepatocytes.Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products.Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.The role of the c-Jun N-terminal kinases 1/2 and receptor-interacting protein kinase 3 in furosemide-induced liver injury Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury.Effect of bile duct ligation on bile acid composition in mouse serum and liver Confirming the Causative Role of Acetaminophen in Indeterminate Acute Liver Failure Using Acetaminophen-Cysteine Adducts.Prolonged Acetaminophen-Protein Adduct Elimination During Renal Failure, Lack of Adduct Removal by Hemodiafiltration, and Urinary Adduct Concentrations After Acetaminophen Overdose.MicroRNAs as Signaling Mediators and Biomarkers of Drug- and Chemical-Induced Liver Injury.Acetaminophen induces JNK/p38 signaling and activates the caspase-9-3-dependent cell death pathway in human mesenchymal stem cells.The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation.Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients.Liver-specific loss of Atg5 causes persistent activation of Nrf2 and protects against acetaminophen-induced liver injury Time course of acetaminophen-protein adducts and acetaminophen metabolites in circulation of overdose patients and in HepaRG cells.Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity.Acetaminophen cytotoxicity is ameliorated in a human liver organotypic co-culture model Geographic variation in utilization of sentinel lymph node biopsy for intermediate thickness cutaneous melanoma Lysosomal instability and cathepsin B release during acetaminophen hepatotoxicity.Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity Bile Acid-Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes Acetaminophen-induced acute liver injury in HCV transgenic mice.Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation Paracetamol (acetaminophen) protein adduct concentrations during therapeutic dosing.Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products.Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications.

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HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity

http://www.wikidata.org/entity/Q34775607

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2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity

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HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity

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HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity

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HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity

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HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity

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HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity

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HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity

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HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity

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Anup Ramachandran

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Douglas E Rollins

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Gordon J Murray

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Hartmut Jaeschke

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Hui-Min Yan

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Mitchell R McGill

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P2860

Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry.

Mechanisms of immune-mediated liver injury.

The oxygen tension modulates acetaminophen-induced mitochondrial oxidant stress and cell injury in cultured hepatocytes

Infection of a human hepatoma cell line by hepatitis B virus.

Acetaminophen-induced acute liver failure: results of a United States multicenter, prospective study.

The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity.

Intracellular signaling mechanisms of acetaminophen-induced liver cell death.

Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy.

The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics.

Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: progress, pitfalls, and prospects.

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974-982

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10.1002/HEP.24132

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3

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21319200

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