Toward the prediction of CNS drug-effect profiles in physiological and pathological conditions using microdialysis and mechanism-based pharmacokinetic-pharmacodynamic modeling.
about
The pharmacokinetic-pharmacodynamic model of azithromycin for lipopolysaccharide-induced depressive-like behavior in miceChallenges of using in vitro data for modeling P-glycoprotein efflux in the blood-brain barrier.Heat shock protein-based therapy as a potential candidate for treating the sphingolipidoses.Prediction of brain clozapine and norclozapine concentrations in humans from a scaled pharmacokinetic model for rat brain and plasma pharmacokineticsChallenges for blood-brain barrier (BBB) screening.Physiologically based pharmacokinetic modelling of drug penetration across the blood-brain barrier--towards a mechanistic IVIVE-based approachPrediction of antiepileptic drug efficacy: the use of intracerebral microdialysis to monitor biophase concentrations.Development of a physiologically-based pharmacokinetic model of the rat central nervous system.Pharmacokinetic applications of microdevices and microsampling techniques.Utility of CSF in translational neuroscience.In vitro, in vivo and in silico models of drug distribution into the brain.Translational aspects of blood-brain barrier transport and central nervous system effects of drugs: from discovery to patients.The effects of antiepileptic drugs on the growth of glioblastoma cell lines.Associating in vitro target binding and in vivo CNS occupancy of serotonin reuptake inhibitors in rats: the role of free drug concentrations.Development of a Physiologically Based Pharmacokinetic/Pharmacodynamic Model to Predict the Impact of Genetic Polymorphisms on the Pharmacokinetics and Pharmacodynamics Represented by Receptor/Transporter Occupancy of Central Nervous System Drugs.Discovery DMPK: changing paradigms in the eighties, nineties and noughties.Comparing translational population-PBPK modelling of brain microdialysis with bottom-up prediction of brain-to-plasma distribution in rat and human.The frontal cortex as a network hub controlling mood and cognition: Probing its neurochemical substrates for improved therapy of psychiatric and neurological disorders.Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics.Application of Microdialysis for Pharmacokinetics of Traditional Chinese Medicine Studies
P2860
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P2860
Toward the prediction of CNS drug-effect profiles in physiological and pathological conditions using microdialysis and mechanism-based pharmacokinetic-pharmacodynamic modeling.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Toward the prediction of CNS d ...... etic-pharmacodynamic modeling.
@ast
Toward the prediction of CNS d ...... etic-pharmacodynamic modeling.
@en
type
label
Toward the prediction of CNS d ...... etic-pharmacodynamic modeling.
@ast
Toward the prediction of CNS d ...... etic-pharmacodynamic modeling.
@en
prefLabel
Toward the prediction of CNS d ...... etic-pharmacodynamic modeling.
@ast
Toward the prediction of CNS d ...... etic-pharmacodynamic modeling.
@en
P2093
P2860
P356
P1433
P1476
Toward the prediction of CNS d ...... etic-pharmacodynamic modeling.
@en
P2093
Dorien Groenendaal
Elizabeth C M de Lange
Paulien G M Ravenstijn
Tamara J van Steeg
P2860
P2888
P304
P356
10.1208/AAPSJ070354
P407
P577
2005-10-07T00:00:00Z
P5875
P6179
1008751681