Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.
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Paralog Specific Hsp90 Inhibitors - A Brief History and a Bright FutureNew insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptorsRoles for Ordered and Bulk Solvent in Ligand Recognition and Docking in Two Related CavitiesStructural and energetic effects of A2A adenosine receptor mutations on agonist and antagonist bindingIdentification of diaryl 5-amino-1,2,4-oxadiazoles as tubulin inhibitors: the special case of 3-(2-fluorophenyl)-5-(4-methoxyphenyl)amino-1,2,4-oxadiazoleStructure-function of the G protein-coupled receptor superfamily.The aryl hydrocarbon receptor mediates raloxifene-induced apoptosis in estrogen receptor-negative hepatoma and breast cancer cells.Structure-based approaches to ligands for G-protein-coupled adenosine and P2Y receptors, from small molecules to nanoconjugates.Fragment-based lead discovery on G-protein-coupled receptors.Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors.Molecular docking screening using agonist-bound GPCR structures: probing the A2A adenosine receptor.John Daly Lecture: Structure-guided Drug Design for Adenosine and P2Y ReceptorsIdentification of Novel Smoothened Ligands Using Structure-Based Docking.The GPCR Network: a large-scale collaboration to determine human GPCR structure and function.Crystal structures of the A2A adenosine receptor and their use in medicinal chemistry.COMU: scope and limitations of the latest innovation in peptide acyl transfer reagents.Structure-based and fragment-based GPCR drug discovery.Novel approaches for targeting the adenosine A2A receptor.Improvements, trends, and new ideas in molecular docking: 2012-2013 in review.Novel 5-arylcarbamoyl-2-methylisoxazolidin-3-yl-3-phosphonates as nucleotide analogues.Recent Advances and Applications of Molecular Docking to G Protein-Coupled Receptors.Breakthrough in GPCR Crystallography and Its Impact on Computer-Aided Drug Design.Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters.
P2860
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P2860
Optimization of adenosine 5'-carboxamide derivatives as adenosine receptor agonists using structure-based ligand design and fragment screening.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
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2012年學術文章
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name
Optimization of adenosine 5'-c ...... design and fragment screening.
@ast
Optimization of adenosine 5'-c ...... design and fragment screening.
@en
type
label
Optimization of adenosine 5'-c ...... design and fragment screening.
@ast
Optimization of adenosine 5'-c ...... design and fragment screening.
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prefLabel
Optimization of adenosine 5'-c ...... design and fragment screening.
@ast
Optimization of adenosine 5'-c ...... design and fragment screening.
@en
P2093
P2860
P50
P356
P1476
Optimization of adenosine 5'-c ...... design and fragment screening.
@en
P2093
Andrei A Gakh
Francesca Deflorian
Raymond C Stevens
P2860
P304
P356
10.1021/JM300095S
P407
P577
2012-04-30T00:00:00Z