Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module
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The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth diseaseMolecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase.Peripheral nerve demyelination caused by a mutant Rho GTPase guanine nucleotide exchange factor, frabin/FGD4Phosphatidylinositol 3,5-bisphosphate: low abundance, high significanceCharcot-Marie-Tooth disease and intracellular trafficAtomic Structure of Dual-Specificity Phosphatase 26, a Novel p53 PhosphataseStructure of the catalytic phosphatase domain of MTMR8: implications for dimerization, membrane association and reversible oxidationSynthetic genetic array analysis of the PtdIns 4-kinase Pik1p identifies components in a Golgi-specific Ypt31/rab-GTPase signaling pathway.Localized PtdIns 3,5-P2 synthesis to regulate early endosome dynamics and fusionEvidence for an elongated dimeric structure of heparin-binding hemagglutinin from Mycobacterium tuberculosisMulti-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domainStructural mechanism of laforin function in glycogen dephosphorylation and lafora disease.Pharmacological targeting of the mitochondrial phosphatase PTPMT1.Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathwaysCooperation of Mtmr8 with PI3K regulates actin filament modeling and muscle development in zebrafishThe role of PI3P phosphatases in the regulation of autophagyExpression, purification, crystallization and preliminary crystallographic analysis of human myotubularin-related protein 3Crystallization and preliminary X-ray crystallographic analysis of the PH-GRAM domain of human MTMR4Acquisition of unprecedented phosphatidylinositol 3,5-bisphosphate rise in hyperosmotically stressed 3T3-L1 adipocytes, mediated by ArPIKfyve-PIKfyve pathway.Voltage-sensing phosphatase: actions and potentials.Endosomal targeting of the phosphoinositide 3-phosphatase MTMR2 is regulated by an N-terminal phosphorylation site.Identification and phylogenetic analyses of VASt, an uncharacterized protein domain associated with lipid-binding domains in Eukaryotes.The myotubularin family of lipid phosphatases in disease and in spermatogenesisPtdIns5P: news and views of its appearance, disappearance and deeds.The Caenorhabditis elegans septin complex is nonpolarMyotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8.PI4P-signaling pathway for the synthesis of a nascent membrane structure in selective autophagy.Coiled-coil domains enhance the membrane association of Salmonella type III effectors.Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients.Disruption of Mtmr2 produces CMT4B1-like neuropathy with myelin outfolding and impaired spermatogenesis.Pathomechanisms of mutant proteins in Charcot-Marie-Tooth disease.Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic.Centronuclear (myotubular) myopathy.Endosomal phosphoinositides and human diseases.Function and dysfunction of the PI system in membrane trafficking.The CMT4B disease-causing proteins MTMR2 and MTMR13/SBF2 regulate AKT signallingDynamic shaping of cellular membranes by phospholipids and membrane-deforming proteins.Multiple disease-linked myotubularin mutations cause NFL assembly defects in cultured cells and disrupt myotubularin dimerization.Dimerization of Laforin is required for its optimal phosphatase activity, regulation of GSK3beta phosphorylation, and Wnt signaling.
P2860
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P2860
Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
Membrane association of myotub ...... oiled-coil dimerization module
@ast
Membrane association of myotub ...... oiled-coil dimerization module
@en
type
label
Membrane association of myotub ...... oiled-coil dimerization module
@ast
Membrane association of myotub ...... oiled-coil dimerization module
@en
prefLabel
Membrane association of myotub ...... oiled-coil dimerization module
@ast
Membrane association of myotub ...... oiled-coil dimerization module
@en
P2093
P2860
P356
P1476
Membrane association of myotub ...... oiled-coil dimerization module
@en
P2093
Imre Berger
Philipp Berger
Ueli Suter
P2860
P304
12177-12182
P356
10.1073/PNAS.2132732100
P407
P577
2003-10-06T00:00:00Z