Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors
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cDNA sequences of two inducible T-cell genesRecombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of themOn the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes. Unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cellIndividual Motile CD4(+) T Cells Can Participate in Efficient Multikilling through Conjugation to Multiple Tumor Cells.Killing of Microbes and Cancer by the Immune System with Three Mammalian Pore-Forming Killer ProteinsPurification and characterization of a T cell specific serine proteinase (TSP-1) from cloned cytolytic T lymphocytesThe MACPF/CDC family of pore-forming toxins.Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: identification of perforin and granzyme B mobilization by functional ERK2.Use of anti-HLA antibodies to mask major histocompatibility complex gene products on tumor cells can enhance susceptibility of these cells to lysis by natural killer cells.Early events in target-cell lysis by cytotoxic T cells.EGFR-targeted granzyme B expressed in NK cells enhances natural cytotoxicity and mediates specific killing of tumor cells.BCL-2 blocks perforin-induced nuclear translocation of granzymes concomitant with protection against the nuclear events of apoptosis.Anti-viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule-bound pathways of apoptosis induction.Identification and sequencing of cDNA clones encoding the granule-associated serine proteases granzymes D, E, and F of cytolytic T lymphocytesSelf-protection of cytotoxic lymphocytes: a soluble form of homologous restriction factor in cytoplasmic granules.Granules of cytolytic T-lymphocytes contain two serine esterases.Perforin rapidly induces plasma membrane phospholipid flip-flopNK cells in gamma-interferon-deficient mice suppress lung innate immunity against Mycoplasma sppIdentification of human granzyme B promoter regulatory elements interacting with activated T-cell-specific proteins: implication of Ikaros and CBF binding sites in promoter activation.Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis.Perforin-mediated target-cell death and immune homeostasis.Functional assessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic functionIsolation and initial characterization of multiple species of T-lymphocyte subset cDNA clones.High activity of N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester serine esterase and cytolytic perforin in cloned cell lines is not demonstrable in in-vivo-induced cytotoxic effector cells.Functional channel formation associated with cytotoxic T-cell granules.Cloning of two genes that are specifically expressed in activated cytotoxic T lymphocytesDNA fragmentation: manifestation of target cell destruction mediated by cytotoxic T-cell lines, lymphotoxin-secreting helper T-cell clones, and cell-free lymphotoxin-containing supernatant.Mechanism of cytotoxicity of human large granular lymphocytes: relationship of the cytotoxic lymphocyte protein to the ninth component (C9) of human complement.Critical role for perforin and Fas-dependent killing of dendritic cells in the control of inflammationImmunohistochemical identification of cytotoxic lymphocytes using human perforin monoclonal antibodyResting and sensitized T lymphocytes exhibit distinct stimulatory (antigen-presenting cell) requirements for growth and lymphokine releaseInterleukin 2 induction of pore-forming protein gene expression in human peripheral blood CD8+ T cells.Proteoglycans in cell-mediated cytotoxicity. Identification, localization, and exocytosis of a chondroitin sulfate proteoglycan from human cloned natural killer cells during target cell lysis.Properties of a purified pore-forming protein (perforin 1) isolated from H-2-restricted cytotoxic T cell granules.Calcium ion concentrations and DNA fragmentation in target cell destruction by murine cloned cytotoxic T lymphocytes.A high proportion of T lymphocytes that infiltrate H-2-incompatible heart allografts in vivo express genes encoding cytotoxic cell-specific serine proteases, but do not express the MEL-14-defined lymph node homing receptor.Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A.Platelet-mediated cytotoxicity. Role of antibody and C3, and localization of the cytotoxic system in membranes.Resistance of cytotoxic T lymphocytes to the lytic effects of their toxic granulesSynergistic roles of granzymes A and B in mediating target cell death by rat basophilic leukemia mast cell tumors also expressing cytolysin/perforin.
P2860
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P2860
Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors
description
1984 nî lūn-bûn
@nan
1984年の論文
@ja
1984年学术文章
@wuu
1984年学术文章
@zh-cn
1984年学术文章
@zh-hans
1984年学术文章
@zh-my
1984年学术文章
@zh-sg
1984年學術文章
@yue
1984年學術文章
@zh
1984年學術文章
@zh-hant
name
Cytolytic activity of purified ...... rge granular lymphocyte tumors
@ast
Cytolytic activity of purified ...... rge granular lymphocyte tumors
@en
type
label
Cytolytic activity of purified ...... rge granular lymphocyte tumors
@ast
Cytolytic activity of purified ...... rge granular lymphocyte tumors
@en
prefLabel
Cytolytic activity of purified ...... rge granular lymphocyte tumors
@ast
Cytolytic activity of purified ...... rge granular lymphocyte tumors
@en
P2093
P2860
P356
P1476
Cytolytic activity of purified ...... rge granular lymphocyte tumors
@en
P2093
C W Reynolds
M P Henkart
P A Henkart
P J Millard
P2860
P356
10.1084/JEM.160.1.75
P407
P577
1984-07-01T00:00:00Z