Proteoglycans in cell-mediated cytotoxicity. Identification, localization, and exocytosis of a chondroitin sulfate proteoglycan from human cloned natural killer cells during target cell lysis.
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Cloning and chromosomal assignment of a human cDNA encoding a T cell- and natural killer cell-specific trypsin-like serine proteaseCytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymesIdentification of granzyme A isolated from cytotoxic T-lymphocyte-granules as one of the proteases encoded by CTL-specific genesSerglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storageCloning, analysis, and expression of murine perforin 1 cDNA, a component of cytolytic T-cell granules with homology to complement component C9.Two proteins targeted to the same lytic granule compartment undergo very different posttranslational processing.Granzyme A released upon stimulation of cytotoxic T lymphocytes activates the thrombin receptor on neuronal cells and astrocytes.Mechanisms regulating the secretion of the promalignancy chemokine CCL5 by breast tumor cells: CCL5's 40s loop and intracellular glycosaminoglycansA null mutation in the perforin gene impairs cytolytic T lymphocyte- and natural killer cell-mediated cytotoxicity.In vitro atrazine-exposure inhibits human natural killer cell lytic granule release.The lytic granules of natural killer cells are dual-function organelles combining secretory and pre-lysosomal compartments.Antigen receptor-regulated exocytosis in cytotoxic T lymphocytes.A high proportion of T lymphocytes that infiltrate H-2-incompatible heart allografts in vivo express genes encoding cytotoxic cell-specific serine proteases, but do not express the MEL-14-defined lymph node homing receptor.A T cell- and natural killer cell-specific, trypsin-like serine protease. Implications of a cytolytic cascade.Isolation of two cDNA sequences which encode cytotoxic cell proteases.Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation.NK cell lytic granules are highly motile at the immunological synapse and require F-actin for post-degranulation persistence.The isolation and characterization of a family of serine protease genes expressed in activated cytotoxic T lymphocytes.Perforin-dependent and -independent pathways of cytotoxicity mediated by lymphocytes.Hydrolysis of tumor cell lipids after CTL-mediated death.Granzymes, cytotoxic granules and cell death: the early work of Dr. Jurg Tschopp.Proteoglycan synthesis in human erythroleukaemia (HEL) cellsUltrastructural evidence that the granules of human natural killer cell clones store membrane in a nonbilayer phase.Expression and enhanced secretion of proteochondroitin sulphate in a metastatic variant of a mouse lymphoma cell line.Dissociation of membrane binding and lytic activities of the lymphocyte pore-forming protein (perforin).Interaction of lymphokine-activated killer cells with susceptible targets does not induce second messenger generation and cytolytic granule exocytosis.Metabolic properties of a homogeneous proteoglycan of a haemopoietic stem cell line, FDCP-mix.Kurloff cell proteoglycans. Evidence for de novo synthesis of chondroitin sulphate proteoglycans by purified Kurloff cells.Chondroitin Sulfate Proteoglycan 4 and Its Potential As an Antibody Immunotherapy Target across Different Tumor Types.Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity.
P2860
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P2860
Proteoglycans in cell-mediated cytotoxicity. Identification, localization, and exocytosis of a chondroitin sulfate proteoglycan from human cloned natural killer cells during target cell lysis.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年学术文章
@wuu
1985年学术文章
@zh-cn
1985年学术文章
@zh-hans
1985年学术文章
@zh-my
1985年学术文章
@zh-sg
1985年學術文章
@yue
1985年學術文章
@zh
1985年學術文章
@zh-hant
name
Proteoglycans in cell-mediated ...... ells during target cell lysis.
@ast
Proteoglycans in cell-mediated ...... ells during target cell lysis.
@en
type
label
Proteoglycans in cell-mediated ...... ells during target cell lysis.
@ast
Proteoglycans in cell-mediated ...... ells during target cell lysis.
@en
prefLabel
Proteoglycans in cell-mediated ...... ells during target cell lysis.
@ast
Proteoglycans in cell-mediated ...... ells during target cell lysis.
@en
P2093
P2860
P356
P1476
Proteoglycans in cell-mediated ...... ells during target cell lysis.
@en
P2093
G T Bartley
J P Caulfield
K F Austen
R E Schmidt
R L Stevens
R P MacDermott
S F Schlossman
P2860
P304
P356
10.1084/JEM.162.6.1771
P407
P577
1985-12-01T00:00:00Z