Absence of the Lyt-2-,L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function.
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Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC moleculeMedical immunology: a new journal for a new subspecialty.Anti-HIV agents targeting the interaction of gp120 with the cellular CD4 receptor.Prevention of diabetes in nonobese diabetic mice by anti-I-A monoclonal antibodies: transfer of protection by splenic T cellsControl of CD4 gene expression: connecting signals to outcomes in T cell development.Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding.Human immunodeficiency virus type 1 gp120 mimics a hidden monomorphic epitope borne by class I major histocompatibility complex heavy chains.Involvement of Lyt-2 and L3T4 in activation of hapten-specific Lyt-2+ L3T4+ T-cell clones.Alpha beta T-lymphocyte depleted mice, a model for gamma delta T-lymphocyte functional studiesEstablishment of a human thymic myoid cell line. Phenotypic and functional characteristics.A T cell receptor-specific blockade of positive selection.Functional epitope analysis of the human CD4 molecule: antibodies that inhibit human immunodeficiency virus type 1 gene expression bind to the immunoglobulin CDR3-like region of CD4Cyclosporin A and the thymus. Immunopathology.Systemic mononuclear-cell vasculitis in MRL/Mp-lpr/lpr mice. A histologic and immunocytochemical analysis.Subtractive isolation of phage-displayed single-chain antibodies to thymic stromal cells by using intact thymic fragmentsThe human immunodeficiency virus gp120 binding site on CD4: delineation by quantitative equilibrium and kinetic binding studies of mutants in conjunction with a high-resolution CD4 atomic structure.CD8 is required during positive selection of CD4-/CD8+ T cellsIntrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. An antigen-dependent microenvironment for T cell differentiation.Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutant mice. III. Normal mouse bone marrow cells enable mev/mev prothymocytes to generate thymocytes after intravenous transferMaturational arrest from CD4+8+ to CD4+8- thymocytes in a mutant strain (LEC) of rat.Differentiation of Ia-reactive CD8+ murine T cells does not require Ia engagement. Implications for the role of CD4 and CD8 accessory molecules in T cell differentiation.Essential role of the interleukin 2-interleukin 2 receptor pathway in thymocyte maturation in vivoPreferential differentiation of T cell receptor specificities based on the MHC glycoproteins encountered during development. Evidence for positive selectionRole of CD4 in thymocyte selection and maturation.Thymic selection and thymic major histocompatibility complex class II expression are abnormal in mice undergoing graft-versus-host reactionsMolecular characterization of major histocompatibility complex class II gene expression and demonstration of antigen-specific T cell response indicate a new phenotype in class II-deficient patients.Precommitment of CD4+CD8+ thymocytes to either CD4 or CD8 lineagesMurine AIDS is an antigen-driven disease: requirements for major histocompatibility complex class II expression and CD4+ T cellsT cell V-gene usage in man in some normal and abnormal situations.Human immunodeficiency virus gp120 binding C'C" ridge of CD4 domain 1 is also involved in interaction with class II major histocompatibility complex molecules.Synergism in the activation of human CD8 T cells by cross-linking the T-cell receptor complex with the CD8 differentiation antigen.The role of the T-cell receptor in thymocyte maturation: effects in vivo of anti-receptor antibodyBone marrow-derived thymic antigen-presenting cells determine self-recognition of Ia-restricted T lymphocytes.Class II major histocompatibility complex molecules regulate the development of the T4+T8- inducer phenotype of cultured human thymocytes.Thymic dendritic cells: phenotype and function.Presence of host-reactive and MHC-restricted T cells in a transplanted severe combined immunodeficient (SCID) patient suggest positive selection and absence of clonal deletion.Tolerance to self antigens shapes the T-cell repertoire.Synthetic peptides derived from the variable regions of an anti-CD4 monoclonal antibody bind to CD4 and inhibit HIV-1 promoter activation in virus-infected cells.Mutational analysis of the structure and function of the CD4 protein.A role for IFN-gamma and NK cells in immune responses to T cell-regulated antigens types 1 and 2.
P2860
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P2860
Absence of the Lyt-2-,L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function.
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年学术文章
@wuu
1985年学术文章
@zh-cn
1985年学术文章
@zh-hans
1985年学术文章
@zh-my
1985年学术文章
@zh-sg
1985年學術文章
@yue
1985年學術文章
@zh
1985年學術文章
@zh-hant
name
Absence of the Lyt-2-,L3T4+ li ...... igen-presenting cell function.
@ast
Absence of the Lyt-2-,L3T4+ li ...... igen-presenting cell function.
@en
type
label
Absence of the Lyt-2-,L3T4+ li ...... igen-presenting cell function.
@ast
Absence of the Lyt-2-,L3T4+ li ...... igen-presenting cell function.
@en
prefLabel
Absence of the Lyt-2-,L3T4+ li ...... igen-presenting cell function.
@ast
Absence of the Lyt-2-,L3T4+ li ...... igen-presenting cell function.
@en
P2093
P2860
P356
P1476
Absence of the Lyt-2-,L3T4+ li ...... igen-presenting cell function.
@en
P2093
A M Kruisbeek
B J Fowlkes
J A Carmen
P2860
P304
P356
10.1084/JEM.161.5.1029
P407
P577
1985-05-01T00:00:00Z