Self recognition in allogeneic thymic chimeras. Self recognition by T helper cells from thymus-engrafted nude mice is restricted to the thymic H-2 haplotype.
about
Model for clonal elimination in the thymus.Positive selection of a T-cell subpopulation in the thymus in which it develops.Primary polyoma virus-induced murine thymic epithelial tumors. A tumor model of thymus physiology.Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy. Immunopathology.Heterogenous graft rejection pathways in class I major histocompatibility complex-disparate combinations and their differential susceptibility to immunomodulation induced by intravenous presensitization with relevant alloantigensGenetic control of the immune response to myoglobins. Both low and high responder T cells tolerant to the other major histocompatibility complex help high but not low responder B cells.Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cellsEarly development of the T cell repertoire. In vivo treatment of neonatal mice with anti-Ia antibodies interferes with differentiation of I-restricted T cells but not K/D-restricted T cells.Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironmentSelf-recognition specificity expressed by T cells from nude mice. Absence of detectable Ia-restricted T cells in nude mice that do exhibit self-K/D-restricted T cell responses.Thymus dictates major histocompatibility complex (MHC) specificity and immune response gene phenotype of class II MHC-restricted T cells but not of class I MHC-restricted T cells.Absence of the Lyt-2-,L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function.Characterization of antigen-specific, Ia-restricted, L3T4+ cytolytic T lymphocytes and assessment of thymic influence on their self specificity.Preferential differentiation of T cell receptor specificities based on the MHC glycoproteins encountered during development. Evidence for positive selectionBone marrow-derived thymic antigen-presenting cells determine self-recognition of Ia-restricted T lymphocytes.Class II major histocompatibility complex molecules regulate the development of the T4+T8- inducer phenotype of cultured human thymocytes.Alternative pathways of T-cell activation and positive clonal selection.Recognition requirements for the activation, differentiation and function of T-helper cells specific for class I MHC alloantigens.The Mls reaction. A regulatory phenomenon.Cell surface antigen marking the stages of murine T cell ontogeny and its functional subsets.Biochemical characterization of a second family of human Ia molecules, HLA-DS, equivalent to murine I-A subregion moleculesIntrathymic tolerance induction: determination of tolerance to class II major histocompatibility complex antigens in maturing T lymphocytes by a bone marrow-derived non-lymphoid thymus cell.
P2860
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P2860
Self recognition in allogeneic thymic chimeras. Self recognition by T helper cells from thymus-engrafted nude mice is restricted to the thymic H-2 haplotype.
description
1982 nî lūn-bûn
@nan
1982 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1982 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1982年の論文
@ja
1982年論文
@yue
1982年論文
@zh-hant
1982年論文
@zh-hk
1982年論文
@zh-mo
1982年論文
@zh-tw
1982年论文
@wuu
name
Self recognition in allogeneic ...... d to the thymic H-2 haplotype.
@ast
Self recognition in allogeneic ...... d to the thymic H-2 haplotype.
@en
Self recognition in allogeneic ...... d to the thymic H-2 haplotype.
@nl
type
label
Self recognition in allogeneic ...... d to the thymic H-2 haplotype.
@ast
Self recognition in allogeneic ...... d to the thymic H-2 haplotype.
@en
Self recognition in allogeneic ...... d to the thymic H-2 haplotype.
@nl
prefLabel
Self recognition in allogeneic ...... d to the thymic H-2 haplotype.
@ast
Self recognition in allogeneic ...... d to the thymic H-2 haplotype.
@en
Self recognition in allogeneic ...... d to the thymic H-2 haplotype.
@nl
P2093
P2860
P356
P1476
Self recognition in allogeneic ...... d to the thymic H-2 haplotype.
@en
P2093
P2860
P304
P356
10.1084/JEM.155.1.339
P407
P577
1982-01-01T00:00:00Z