VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin.
about
Structural recognition of a novel fibrinogen gamma chain sequence (117-133) by intercellular adhesion molecule-1 mediates leukocyte-endothelium interactionPropolypeptide of von Willebrand factor is a novel ligand for very late antigen-4 integrinDirect association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAKSignal transduction from the extracellular matrixStructure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytesThe Dipeptidyl Peptidase Family, Prolyl Oligopeptidase, and Prolyl Carboxypeptidase in the Immune System and Inflammatory Disease, Including AtherosclerosisCell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrinsVLA-4-fibronectin interaction is required for the terminal differentiation of human bone marrow cells capable of spontaneous and high rate immunoglobulin secretionEffect of the interaction between fibronectin and VLA-4 on the proliferation of human B cells, especially a novel human B-cell line, OPM-3Role of the β1 integrin molecule in T-cell activation and migration.Fibronectins, their fibrillogenesis, and in vivo functions.Effect of natalizumab on circulating CD4+ T-cells in multiple sclerosis.HTLV-I Tax induces and associates with Crk-associated substrate lymphocyte type (Cas-L).The pathophysiologic role of alpha 4 integrins in vivoProlonged impairment of very late activating antigen-mediated T cell proliferation via the CD3 pathway after T cell-depleted allogeneic bone marrow transplantation.Macrophage-colony-stimulating factor regulates expression of the integrins alpha 4 beta 1 and alpha 5 beta 1 by murine bone marrow macrophages.Beta 1 integrins signal lipid second messengers required during cell adhesion.Sensing the environment: a historical perspective on integrin signal transduction.Fibronectin receptor defects in NOD mouse leucocytes: possible consequences for type 1 diabetes.Analysis of T cell stimulation by superantigen plus major histocompatibility complex class II molecules or by CD3 monoclonal antibody: costimulation by purified adhesion ligands VCAM-1, ICAM-1, but not ELAM-1.Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein.Contrasting roles for integrin beta 1 and beta 5 cytoplasmic domains in subcellular localization, cell proliferation, and cell migration.The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent.Therapeutic anti-integrin (alpha4 and alphaL) monoclonal antibodies: two-edged swords?T cell receptor- and beta 1 integrin-mediated signals synergize to induce tyrosine phosphorylation of focal adhesion kinase (pp125FAK) in human T cellsFractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow.Cytokines in contextA VCAM-like adhesion molecule on murine bone marrow stromal cells mediates binding of lymphocyte precursors in culture.Requirement for VLA-4 and VLA-5 integrins in lymphoma cells binding to and migration beneath stromal cells in cultureHIV-1 infection of human T lymphocytes results in enhanced alpha 5 beta 1 integrin expression.Tumor cell surface alpha 4 beta 1 integrin mediates adhesion to vascular endothelium: demonstration of an interaction with the N-terminal domains of INCAM-110/VCAM-1New insights into the pharmacokinetics and pharmacodynamics of natalizumab treatment for patients with multiple sclerosis, obtained from clinical and in vitro studies.Integrins as a primary signal transduction molecule regulating monocyte immediate-early gene induction.T-cell activation molecule 4-1BB binds to extracellular matrix proteins.Blockade of CD49d (alpha4 integrin) on intrapulmonary but not circulating leukocytes inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma.The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin.CD9 negatively regulates CD26 expression and inhibits CD26-mediated enhancement of invasive potential of malignant mesothelioma cellsVascular cell adhesion molecule 1 induces T-cell antigen receptor-dependent activation of CD4+T lymphocytesSignal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.Fibronectin synthesis by activated T lymphocytes: up-regulation of a surface-associated isoform with signalling function.
P2860
Q24309459-65DCFDA4-8913-43F4-95FD-2A14B6686182Q24310247-1C24376B-A458-4882-A009-C09833DFAAF8Q24310862-D35D82B9-7000-42DB-A2C7-98B5DAE56A33Q24675031-BCDDE055-9559-45B7-B1D3-C06FB9588CD8Q24676931-9936E79F-C1CF-4CED-AED9-6704BD830EDDQ26795473-9C428F2C-C309-48DD-871C-04260C0422CAQ28118870-C3AB74CF-64C9-4163-AA69-F3DABDED4656Q28647178-0D6E9632-A499-4EDE-BAEA-64D083B02D60Q28647333-9996126A-5B3E-4C00-937D-66CE260B241AQ30175238-6B75653D-3023-4C51-99CD-073D45F9B791Q30421926-BD283431-8BEB-4D46-B229-10BB44668876Q31108462-CDFE5205-B2B1-4A0A-8124-3749F59175E5Q31135450-42881462-D1D4-4B7C-8534-7E8E5FC4E855Q34155588-1EDA2F66-9DAF-4CE0-AC4D-C3E9E61C0AFCQ34180880-FAAC9FA1-811B-4024-AADC-121DD0D03599Q34295875-49797C77-C829-4A2B-85CA-CA801547C73FQ34452102-9002CD89-2EF2-44CB-8B57-B852ADF46D62Q34594621-E090C874-CA71-4E7D-A18A-3A2F4B9B55BFQ35828157-19FCFFC8-E493-423A-9806-D4D1D6E67BCCQ36230408-FB2F0E57-F24E-47F7-86DA-C6326ADE57CBQ36231170-37799CE0-C7AF-412F-87B1-BD97D2FC2AFFQ36234185-0F900C42-1BC6-469B-A9EF-A7F520CCDDB5Q36234250-B77DDAD5-C4D5-4AA8-B093-B37DCEAE40D7Q36291069-AA1DF221-346C-4298-A625-77B124BBDADDQ36365690-0D13BA4A-AA74-44FF-8FD0-4E8CC10BE25BQ36404237-1AEBA470-AEAE-4856-8282-906983AB78F7Q36529819-EE8C0F14-1415-44AA-880C-58AC956D75DAQ36530133-80250B52-1B13-4658-88D5-EB28A4D5EBDDQ36532072-CAD1A6CB-2E95-4374-BA13-8E8D12F52229Q36532729-4606C195-B3BD-4A5D-95FC-124A46FE3AB8Q36744271-9BFC75C2-E6B4-4A4C-91F6-6A9B590E4E6AQ37045253-89B775C6-E839-45E4-9B82-1774C6CD33FBQ37219576-014092D7-2C12-4DFC-BAAA-09C15AE83B32Q37277146-F55688F3-09F8-480D-89A2-A913314056DCQ37376457-96B7B2B7-594A-4CF6-8F0A-46DEA735C593Q37388211-5D316E50-FDB1-40B8-933C-0B1A8224BE62Q37510305-14F691FC-6C9B-4F78-BC49-377AD5843BCAQ37553147-5CE78A81-F42F-416F-8418-3B91012EB892Q37597345-D62BA7BF-08BB-46BE-8B07-74D29433083AQ38312670-5762E53B-79D3-4265-BB32-DAE86FE3876D
P2860
VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
1990年學術文章
@zh
1990年學術文章
@zh-hant
name
VLA-4 mediates CD3-dependent C ...... spliced domain of fibronectin.
@ast
VLA-4 mediates CD3-dependent C ...... spliced domain of fibronectin.
@en
type
label
VLA-4 mediates CD3-dependent C ...... spliced domain of fibronectin.
@ast
VLA-4 mediates CD3-dependent C ...... spliced domain of fibronectin.
@en
prefLabel
VLA-4 mediates CD3-dependent C ...... spliced domain of fibronectin.
@ast
VLA-4 mediates CD3-dependent C ...... spliced domain of fibronectin.
@en
P2093
P2860
P356
P1476
VLA-4 mediates CD3-dependent C ...... spliced domain of fibronectin.
@en
P2093
A Komoriya
C Morimoto
K M Yamada
M J Humphries
S F Schlossman
P2860
P304
P356
10.1084/JEM.172.4.1185
P407
P577
1990-10-01T00:00:00Z