The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin.
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Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castleThe circumventricular organs participate in the immunopathogenesis of experimental autoimmune encephalomyelitis.Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor modelsLive cell imaging techniques to study T cell trafficking across the blood-brain barrier in vitro and in vivoLeukocyte integrins: role in leukocyte recruitment and as therapeutic targets in inflammatory diseaseTemporal pattern of ICAM-I mediated regulatory T cell recruitment to sites of inflammation in adoptive transfer model of multiple sclerosis.Lymphocyte migration to inflamed lacrimal glands is mediated by vascular cell adhesion molecule-1/alpha(4)beta(1) integrin, peripheral node addressin/l-selectin, and lymphocyte function-associated antigen-1 adhesion pathwaysTherapeutic targeting of STAT3 (signal transducers and activators of transcription 3) pathway inhibits experimental autoimmune uveitisBeta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunityComparison of immortalized bEnd5 and primary mouse brain microvascular endothelial cells as in vitro blood-brain barrier models for the study of T cell extravasation.The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury.Neuroimmunotherapies Targeting T Cells: From Pathophysiology to Therapeutic Applications.CNS elevation of vascular and not mucosal addressin cell adhesion molecules in patients with multiple sclerosis.Quantitative lymphatic vessel trait analysis suggests Vcam1 as candidate modifier gene of inflammatory bowel disease.Involvement of the choroid plexus in central nervous system inflammation.Targeting leukocyte migration and adhesion in Crohn's disease and ulcerative colitis.Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice.A humanized monoclonal antibody targeting the β7 integrin selectively blocks intestinal homing of T lymphocytes.Early treatment with anti-VLA-4 mAb can prevent the infiltration and/or development of pathogenic CD11b+CD4+ T cells in the CNS during progressive EAE.Differential roles of ICAM-1 and VCAM-1 in leukocyte-endothelial cell interactions in skin and brain of MRL/faslpr miceCutting edge: loss of α4 integrin expression differentially affects the homing of Th1 and Th17 cellsAlpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvesselsAn inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endotheliumEndothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis.The central nervous system is a target of acute graft versus host disease in mice.A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitisNotch signaling regulates T cell accumulation and function in the central nervous system during experimental autoimmune encephalomyelitis.Pharmacological characterization of PF-00547659, an anti-human MAdCAM monoclonal antibodyPostarrest stalling rather than crawling favors CD8(+) over CD4(+) T-cell migration across the blood-brain barrier under flow in vitro.SAP suppresses the development of experimental autoimmune encephalomyelitis in C57BL/6 mice.The Skin-Brain Connection Hypothesis, Bringing Together CCL27-Mediated T-Cell Activation in the Skin and Neural Cell Damage in the Adult Brain.DARC shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous system inflammation.A Novel Cervical Spinal Cord Window Preparation Allows for Two-Photon Imaging of T-Cell Interactions with the Cervical Spinal Cord Microvasculature during Experimental Autoimmune Encephalomyelitis.Astrocytes in the tempest of multiple sclerosis.T-cell trafficking in the central nervous system.Current multiple sclerosis treatments have improved our understanding of MS autoimmune pathogenesis.PSGL-1 and E/P-selectins are essential for T-cell rolling in inflamed CNS microvessels but dispensable for initiation of EAE.Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the α4β1-integrin.Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems.Microflora reactive IL-10 producing regulatory T cells are present in the colon of IL-2 deficient mice but lack efficacious inhibition of IFN-gamma and TNF-alpha production.
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P2860
The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrin.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 1998
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The development of experimenta ...... but not alpha4beta7-integrin.
@en
The development of experimenta ...... but not alpha4beta7-integrin.
@nl
type
label
The development of experimenta ...... but not alpha4beta7-integrin.
@en
The development of experimenta ...... but not alpha4beta7-integrin.
@nl
prefLabel
The development of experimenta ...... but not alpha4beta7-integrin.
@en
The development of experimenta ...... but not alpha4beta7-integrin.
@nl
P2093
P2860
P356
P1476
The development of experimenta ...... but not alpha4beta7-integrin.
@en
P2093
Engelhardt B
Laschinger M
Samulowitz U
P2860
P304
P356
10.1172/JCI4271
P407
P577
1998-12-01T00:00:00Z