Isolation of novel synthetic prion strains by amplification in transgenic mice coexpressing wild-type and anchorless prion proteins.
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Insights into Mechanisms of Chronic NeurodegenerationEfficient uptake and dissemination of scrapie prion protein by astrocytes and fibroblasts from adult hamster brainN-Terminal Helix-Cap in α-Helix 2 Modulates β-State Misfolding in Rabbit and Hamster Prion ProteinsRecombinant prion protein refolded with lipid and RNA has the biochemical hallmarks of a prion but lacks in vivo infectivityIncreased infectivity of anchorless mouse scrapie prions in transgenic mice overexpressing human prion proteinA Structural and Functional Comparison Between Infectious and Non-Infectious Autocatalytic Recombinant PrP Conformers.PrPSc-Specific Antibody Reveals C-Terminal Conformational Differences between Prion Strains.Getting to the core of prion superstructural variability.Pathology of SSLOW, a transmissible and fatal synthetic prion protein disorder, and comparison with naturally occurring classical transmissible spongiform encephalopathies.Dissociation of prion protein amyloid seeding from transmission of a spongiform encephalopathyPrP aggregation can be seeded by pre-formed recombinant PrP amyloid fibrils without the replication of infectious prionsAmyloid fibrils from the N-terminal prion protein fragment are infectious.Distinct patterns of spread of prion infection in brains of mice expressing anchorless or anchored forms of prion proteinPrion disease and the innate immune system.Proteomics applications in prion biology and structure.Infectious prions and proteinopathies.Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates.Immunodetection of PrPSc Using Western Immunoblotting Techniques.PrP P102L and nearby lysine mutations promote spontaneous in vitro formation of transmissible prions.Dissociation of recombinant prion autocatalysis from infectivity.Conformational properties of prion strains can be transmitted to recombinant prion protein fibrils in real-time quaking-induced conversion.The many shades of prion strain adaptation.Structural conservation of prion strain specificities in recombinant prion protein fibrils in real-time quaking-induced conversion.
P2860
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P2860
Isolation of novel synthetic prion strains by amplification in transgenic mice coexpressing wild-type and anchorless prion proteins.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
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name
Isolation of novel synthetic p ...... and anchorless prion proteins.
@ast
Isolation of novel synthetic p ...... and anchorless prion proteins.
@en
type
label
Isolation of novel synthetic p ...... and anchorless prion proteins.
@ast
Isolation of novel synthetic p ...... and anchorless prion proteins.
@en
prefLabel
Isolation of novel synthetic p ...... and anchorless prion proteins.
@ast
Isolation of novel synthetic p ...... and anchorless prion proteins.
@en
P2093
P2860
P356
P1433
P1476
Isolation of novel synthetic p ...... and anchorless prion proteins.
@en
P2093
Andrew G Hughson
Brent Race
David W Dorward
Gerald S Baron
Gregory J Raymond
Jason R Hollister
Lynne D Raymond
Ravindra Kodali
Roger A Moore
P2860
P304
11763-11778
P356
10.1128/JVI.01353-12
P407
P577
2012-08-22T00:00:00Z