Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene
about
Coevolution of TCR-MHC interactions: conserved MHC tertiary structure is not sufficient for interactions with the TCR.Naturally occurring TAP-dependent specific T-cell tolerance for a variant of an immunodominant retroviral cytotoxic T-lymphocyte epitope.A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surfaceT cell receptor interactions with class I heavy-chain influence T cell selection.MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis.HLA class I transgenic mice: development, utilisation and improvement.Misfolded major histocompatibility complex class I molecules accumulate in an expanded ER-Golgi intermediate compartmentPositive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules.Biosynthesis of major histocompatibility complex molecules and generation of T cells in Ii TAP1 double-mutant mice.Mature T cell reactivity altered by peptide agonist that induces positive selection.
P2860
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P2860
Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene
description
1995 nî lūn-bûn
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1995年の論文
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1995年学术文章
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1995年学术文章
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1995年学术文章
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1995年学术文章
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1995年学术文章
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1995年學術文章
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1995年學術文章
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1995年學術文章
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name
Increase in positive selection ...... beta 2-microglobulin transgene
@ast
Increase in positive selection ...... beta 2-microglobulin transgene
@en
type
label
Increase in positive selection ...... beta 2-microglobulin transgene
@ast
Increase in positive selection ...... beta 2-microglobulin transgene
@en
prefLabel
Increase in positive selection ...... beta 2-microglobulin transgene
@ast
Increase in positive selection ...... beta 2-microglobulin transgene
@en
P2093
P2860
P356
P1476
Increase in positive selection ...... beta 2-microglobulin transgene
@en
P2093
H L Ploegh
H Martien van Santen
P G Rickardt
S Tonegawa
P2860
P304
P356
10.1084/JEM.181.2.787
P407
P50
P577
1995-02-01T00:00:00Z