Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.
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Degeneracy of antigen recognition as the molecular basis for the high frequency of naive A2/Melan-a peptide multimer(+) CD8(+) T cells in humansPositive selection in the thymus: an enigma wrapped in a mystery.αβ T cell receptors as predictors of health and diseaseRemoval of C-terminal SRC kinase from the immune synapse by a new binding proteinImmune evasion proteins of murine cytomegalovirus preferentially affect cell surface display of recently generated peptide presentation complexes.Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection.Paradoxical intrathymic positive selection in mice with only a covalently presented agonist peptideReview article: thymus organ cultures and T-cell receptor repertoire development.Lymphocytes selected in allogeneic thymic epithelium mediate dominant tolerance toward tissue grafts of the thymic epithelium haplotypeRevisiting thymic positive selection and the mature T cell repertoire for antigen.Immunodominant minor histocompatibility antigens expressed by mouse leukemic cells can serve as effective targets for T cell immunotherapy.Cross-reactivity in T-cell antigen recognition.Negative selection assay based on stimulation of T cell receptor transgenic thymocytes with peptide-MHC tetramersReverse genetics modification of cytomegalovirus antigenicity and immunogenicity by CD8 T-cell epitope deletion and insertion.Altered positive selection due to corecognition of floppy peptide/MHC II conformers supports an integrative model of thymic selection.Natural polymorphisms in Tap2 influence negative selection and CD4∶CD8 lineage commitment in the ratDiversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact.Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice.A T cell receptor-specific blockade of positive selection.The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cellsInteractions with multiple peptide ligands determine the fate of developing thymocytes.Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes.Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules.Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgenePeptide influences the folding and intracellular transport of free major histocompatibility complex class I heavy chains.Unresponsiveness to a self-peptide of mouse lysozyme owing to hindrance of T cell receptor-major histocompatibility complex/peptide interaction caused by flanking epitopic residuesA single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity.A naturally processed mitochondrial self-peptide in complex with thymic MHC molecules functions as a selecting ligand for a viral-specific T cell receptor.A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex.The selection of M3-restricted T cells is dependent on M3 expression and presentation of N-formylated peptides in the thymus.Selection of antigen-specific T cells by a single IEk peptide combinationQuantitative analysis of the T cell repertoire selected by a single peptide-major histocompatibility complex.Modulation of thymic selection by expression of an immediate-early gene, early growth response 1 (Egr-1).Molecular basis for the recognition of two structurally different major histocompatibility complex/peptide complexes by a single T-cell receptor.Inhibition of intrathymic T cell development by expression of a transgenic antagonist peptide.Genetic susceptibility to type 1 diabetes in the intracellular pathway of antigen processing - a subject review and cross-study comparison.Functional development of the T cell receptor for antigenAn endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181aT cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens.Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch
P2860
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P2860
Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Positive selection of CD8+ T c ...... in fetal thymic organ culture.
@ast
Positive selection of CD8+ T c ...... in fetal thymic organ culture.
@en
type
label
Positive selection of CD8+ T c ...... in fetal thymic organ culture.
@ast
Positive selection of CD8+ T c ...... in fetal thymic organ culture.
@en
prefLabel
Positive selection of CD8+ T c ...... in fetal thymic organ culture.
@ast
Positive selection of CD8+ T c ...... in fetal thymic organ culture.
@en
P2093
P2860
P356
P1476
Positive selection of CD8+ T c ...... in fetal thymic organ culture.
@en
P2093
K A Hogquist
P2860
P304
P356
10.1084/JEM.177.5.1469
P407
P577
1993-05-01T00:00:00Z