Epidermal cancer associated with expression of human papillomavirus type 16 E6 and E7 oncogenes in the skin of transgenic mice
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Animal models to study the mutational landscape for oral cavity and oropharyngeal cancersBeta-catenin accelerates human papilloma virus type-16 mediated cervical carcinogenesis in transgenic miceViruses and human cancers: a long road of discovery of molecular paradigms.Papillomavirus E6 oncoproteins.The E7 oncoprotein of human papillomavirus type 16 stabilizes p53 through a mechanism independent of p19(ARF).Transgenic models of retinoblastoma: what they tell us about its cause and treatmentIntegration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis.Listeria-based vaccines can overcome tolerance by expanding low avidity CD8+ T cells capable of eradicating a solid tumor in a transgenic mouse model of cancer.A synthetic E7 gene of human papillomavirus type 16 that yields enhanced expression of the protein in mammalian cells and is useful for DNA immunization studies.E6/E7 expression of human papillomavirus type 20 (HPV-20) and HPV-27 influences proliferation and differentiation of the skin in UV-irradiated SKH-hr1 transgenic miceGenetic predisposition and parameters of malignant progression in K14-HPV16 transgenic mice.The HPV 16 genome induces carcinomas and T-cell lymphomas in transgenic miceIntegration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cellsSquamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene.Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16.Both conserved region 1 (CR1) and CR2 of the human papillomavirus type 16 E7 oncogene are required for induction of epidermal hyperplasia and tumor formation in transgenic mice.Mechanisms of human papillomavirus-induced oncogenesis.Bioluminescent imaging of HPV-positive oral tumor growth and its response to image-guided radiotherapyProgressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic miceCellular transformation by human papillomaviruses: lessons learned by comparing high- and low-risk virusesIncreased incidence of squamous cell carcinomas in Mastomys natalensis papillomavirus E6 transgenic mice during two-stage skin carcinogenesis.Moving forward with human papillomavirus immunotherapies.Comparison of commercial hybridization and automated transcription-mediated amplification modalities for detection of high-risk human papillomavirus nucleic acid.Validation of an HPV16-mediated carcinogenesis mouse model.Establishment and characterization of a penile cancer cell line, penl1, with a deleterious TP53 mutation as a paradigm of HPV-negative penile carcinogenesis.HPV E6 oncoprotein as a potential therapeutic target in HPV related cancers.The HPV16 oncogenes cause aberrant stem cell mobilization.E6/E7 oncogenes in epithelial suprabasal layers and estradiol promote cervical growth and ear regeneration.A systematic analysis of human papillomavirus (HPV) E6 PDZ substrates identifies MAGI-1 as a major target of HPV type 16 (HPV-16) and HPV-18 whose loss accompanies disruption of tight junctions.Skin hyperproliferation and susceptibility to chemical carcinogenesis in transgenic mice expressing E6 and E7 of human papillomavirus type 38.Papilloma formation by cottontail rabbit papillomavirus requires E1 and E2 regulatory genes in addition to E6 and E7 transforming genes.HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis.Human Papillomavirus and the Stroma: Bidirectional Crosstalk during the Virus Life Cycle and Carcinogenesis.Restoration of MAGI-1 expression in human papillomavirus-positive tumor cells induces cell growth arrest and apoptosis.Targeted expression of the E6 and E7 oncogenes of human papillomavirus type 16 in the epidermis of transgenic mice elicits generalized epidermal hyperplasia involving autocrine factors.Thymic hyperplasia and lung carcinomas in a line of mice transgenic for keratin 5-driven HPV16 E6/E7 oncogenes.Strong synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors.Cidofovir incorporation into human keratinocytes with episomal HPV 16 results in nonselective cytotoxicity.Human papillomavirus oncogenes reprogram the cervical cancer microenvironment independently of and synergistically with estrogen.A vaccine conjugate of 'ISCAR' immunocarrier and peptide epitopes of the E7 cervical cancer-associated protein of human papillomavirus type 16 elicits specific Th1- and Th2-type responses in immunized mice in the absence of oil-based adjuvants.
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P2860
Epidermal cancer associated with expression of human papillomavirus type 16 E6 and E7 oncogenes in the skin of transgenic mice
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Epidermal cancer associated wi ...... in the skin of transgenic mice
@ast
Epidermal cancer associated wi ...... in the skin of transgenic mice
@en
type
label
Epidermal cancer associated wi ...... in the skin of transgenic mice
@ast
Epidermal cancer associated wi ...... in the skin of transgenic mice
@en
prefLabel
Epidermal cancer associated wi ...... in the skin of transgenic mice
@ast
Epidermal cancer associated wi ...... in the skin of transgenic mice
@en
P2093
P2860
P356
P1476
Epidermal cancer associated wi ...... in the skin of transgenic mice
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.12.5583
P407
P577
1993-06-01T00:00:00Z