MRL-lpr/lpr mice exhibit a defect in maintaining developmental arrest and follicular exclusion of anti-double-stranded DNA B cells.
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Somatic mutagenesis in autoimmunityIDO2: A Pathogenic Mediator of Inflammatory AutoimmunitySpontaneous autoimmunity in mice that carry an IghV partial transgene: a required arginine in VHCDR3.Specific recognition of a dsDNA sequence motif by an immunoglobulin VH homodimer.Stage dependent aberrant regulation of cytokine-STAT signaling in murine systemic lupus erythematosus.Receptor editing in peripheral B cell tolerance.Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity.Despite ubiquitous autoantigen expression, arthritogenic autoantibody response initiates in the local lymph nodeFrom T to B and back again: positive feedback in systemic autoimmune disease.Activation-induced deaminase-deficient MRL/lpr mice secrete high levels of protective antibodies against lupus nephritis.Predominant role for activation-induced cytidine deaminase in generating IgG anti-nucleosomal antibodies of murine SLE.The regulation and activation of lupus-associated B cells.Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell helpAbrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice.Dual-reactive B cells are autoreactive and highly enriched in the plasmablast and memory B cell subsets of autoimmune mice.Anti-DNA B cells in MRL/lpr mice show altered differentiation and editing pattern.Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in FaslTLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation.A bacterial artificial chromosome transgene with polymorphic Cd72 inhibits the development of glomerulonephritis and vasculitis in MRL-Faslpr lupus miceRegulation of lupus-related autoantibody production and clinical disease by Toll-like receptorsDeletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice.B-cell anergy: from transgenic models to naturally occurring anergic B cells?Autoantibody production in lpr/lpr gld/gld mice reflects accumulation of CD4+ effector cells that are resistant to regulatory T cell activity.ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity.A new site-directed transgenic rheumatoid factor mouse model demonstrates extrafollicular class switch and plasmablast formationFas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction.The role of activation-induced deaminase in lupus nephritis.Aberrant B cell selection and activation in systemic lupus erythematosus.Contributions of B cells to lupus pathogenesisNew insights into the immunopathogenesis of systemic lupus erythematosus.Activation of diverse repertoires of autoreactive T cells enhances the loss of anti-dsDNA B cell tolerance.C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice.Aiolos Overexpression in Systemic Lupus Erythematosus B Cell Subtypes and BAFF-Induced Memory B Cell Differentiation Are Reduced by CC-220 Modulation of Cereblon ActivityT cell-independent and toll-like receptor-dependent antigen-driven activation of autoreactive B cells.Spontaneous loss of tolerance of autoreactive B cells in Act1-deficient rheumatoid factor transgenic mice.Loss of Immune Tolerance Is Controlled by ICOS in Sle1 Mice.Anti-chromatin antibodies drive in vivo antigen-specific activation and somatic hypermutation of rheumatoid factor B cells at extrafollicular sites.Autoreactive MZ and B-1 B-cell activation by Faslpr is coincident with an increased frequency of apoptotic lymphocytes and a defect in macrophage clearance.A fail-safe mechanism for negative selection of isotype-switched B cell precursors is regulated by the Fas/FasL pathway.The regulation of autoreactive B cells during innate immune responses.
P2860
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P2860
MRL-lpr/lpr mice exhibit a defect in maintaining developmental arrest and follicular exclusion of anti-double-stranded DNA B cells.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
MRL-lpr/lpr mice exhibit a def ...... i-double-stranded DNA B cells.
@ast
MRL-lpr/lpr mice exhibit a def ...... i-double-stranded DNA B cells.
@en
type
label
MRL-lpr/lpr mice exhibit a def ...... i-double-stranded DNA B cells.
@ast
MRL-lpr/lpr mice exhibit a def ...... i-double-stranded DNA B cells.
@en
prefLabel
MRL-lpr/lpr mice exhibit a def ...... i-double-stranded DNA B cells.
@ast
MRL-lpr/lpr mice exhibit a def ...... i-double-stranded DNA B cells.
@en
P2093
P2860
P356
P1476
MRL-lpr/lpr mice exhibit a def ...... i-double-stranded DNA B cells.
@en
P2093
P2860
P304
P356
10.1084/JEM.189.11.1799
P407
P577
1999-06-01T00:00:00Z