Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice. - Wikidata - awgldk - TriplyDB

Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice.

Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice.

http://www.wikidata.org/entity/Q36253581

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Role of Natural Autoantibodies and Natural IgM Anti-Leucocyte Autoantibodies in Health and Disease Mechanisms of Kidney Injury in Lupus Nephritis - the Role of Anti-dsDNA Antibodies Regulation of Aicda expression and AID activity Somatic mutagenesis in autoimmunity Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein P2X7 blockade attenuates murine lupus nephritis by inhibiting activation of the NLRP3/ASC/caspase 1 pathway.AID in aging and autoimmune diseases.Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells Potential roles of activation-induced cytidine deaminase in promotion or prevention of autoimmunity in humans MicroRNA Regulation in Systemic Lupus Erythematosus Pathogenesis Serum autoantibodies in pristane induced lupus are regulated by neutrophil gelatinase associated lipocalin Enhanced auto-antibody production and Mott cell formation in FcμR-deficient autoimmune mice.PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and Blimp-1 expression for epigenetic modulation of antibody and autoantibody responses.Activation-induced deaminase-deficient MRL/lpr mice secrete high levels of protective antibodies against lupus nephritis.Systemic lupus erythematosus patients contain significantly less igm against mono-methylated lysine than healthy subjects Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.Reduced B lymphoid kinase (Blk) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL/6-lpr/lpr mice.Predominant role for activation-induced cytidine deaminase in generating IgG anti-nucleosomal antibodies of murine SLE.HSP90 inhibitors decrease AID levels and activity in mice and in human cells.Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase ζ activity.Iron inhibits activation-induced cytidine deaminase enzymatic activity and modulates immunoglobulin class switch DNA recombination.Inhibition of the catalytic function of activation-induced cytidine deaminase promotes apoptosis of germinal center B cells in BXD2 mice.Autoantibodies against mono- and tri-methylated lysine display similar but also distinctive characteristics.Activation-induced deaminase contributes to the antibody-independent role of B cells in the development of autoimmunity.Isoflurane attenuates murine lupus nephritis by inhibiting NLRP3 inflammasome activation.Critical role of activation induced cytidine deaminase in experimental autoimmune encephalomyelitis.IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice.Defects in lysosomal maturation facilitate the activation of innate sensors in systemic lupus erythematosus.The constant region contributes to the antigenic specificity and renal pathogenicity of murine anti-DNA antibodies.Apoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus Erythematosus.Estrogen directly activates AID transcription and function Women, autoimmunity, and cancer: a dangerous liaison between estrogen and activation-induced deaminase?AID dysregulation in lupus-prone MRL/Fas(lpr/lpr) mice increases class switch DNA recombination and promotes interchromosomal c-Myc/IgH loci translocations: modulation by HoxC4 The multi-faceted influences of estrogen on lymphocytes: toward novel immuno-interventions strategies for autoimmunity management.Activation-induced cytidine deaminase and aberrant germinal center selection in the development of humoral autoimmunities Small Molecule Inhibition of Rab7 Impairs B Cell Class Switching and Plasma Cell Survival To Dampen the Autoantibody Response in Murine Lupus.Hormones and AID: balancing immunity and autoimmunity.The role of somatic hypermutation in the generation of pathogenic antibodies in SLE.Gonadal steroids and humoral immunity.

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Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice.

http://www.wikidata.org/entity/Q36253581

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice.

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Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice.

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type

label

Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice.

@ast

Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice.

@en

prefLabel

Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice.

@ast

Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice.

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Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice.

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P2093

Chuancang Jiang

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Grace Kissling

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Julie Foley

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Marilyn Diaz

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Micheal Jokinen

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Natasha Clayton

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Ronald Herbert

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P2860

Clearance of Apoptotic Cells in Human SLE

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

B cells in rheumatoid arthritis

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice

The double edged sword of the immune response: mutational analysis of a murine anti-pneumococcal, anti-DNA antibody

Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

IgG Fc receptors

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

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