Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation. - Wikidata - awgldk - TriplyDB

Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

http://www.wikidata.org/entity/Q36368577

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The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis Granzymes: a family of lymphocyte granule serine proteases A quarter century of granzymes GraBCas: a bioinformatics tool for score-based prediction of Caspase- and Granzyme B-cleavage sites in protein sequences.Genes involved in pancreatic islet cell rejuvenation The Janus Face of Death Receptor Signaling during Tumor Immunoediting Granzyme M mediates a novel form of perforin-dependent cell death The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species Cytotoxic proteins and therapeutic targets in severe cutaneous adverse reactions Pan-Bcl-2 inhibitor AT-101 enhances tumor cell killing by EGFR targeted T cells A natural genetic variant of granzyme B confers lethality to a common viral infection Granzyme B enters the mitochondria in a Sam50-, Tim22- and mtHsp70-dependent manner to induce apoptosis.Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice.Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737 A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid.Melanoma inhibitor of apoptosis protein (ML-IAP) is a target for immune-mediated tumor destruction.BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention.Mutations to bid cleavage sites protect hepatocytes from apoptosis after ischemia/reperfusion injury Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells.Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors.Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK.Granzyme A activates another way to die Cytotoxic and non-cytotoxic roles of the CTL/NK protease granzyme B.Discordant regulation of granzyme H and granzyme B expression in human lymphocytes.Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice.Advances in the non-surgical treatment of melanoma.Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis.Perforin-mediated target-cell death and immune homeostasis.Death by a thousand cuts: granzyme pathways of programmed cell death RNA interference for improving the outcome of islet transplantation.A triple-mutated allele of granzyme B incapable of inducing apoptosis.The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.Expression of Bcl-2 family member Bid in normal and malignant tissues.Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.Granzymes and perforin in solid organ transplant rejection.Tumor escape from killing: role of killer inhibitory receptors and acquisition of tumor resistance to cell death.Toxoplasma gondii inhibits granzyme B-mediated apoptosis by the inhibition of granzyme B function in host cells Targeted apoptosis activation with GrB/scFvMEL modulates melanoma growth, metastatic spread, chemosensitivity, and radiosensitivity.Viral versus cellular BCL-2 proteins.

P2860

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P2860

Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

http://www.wikidata.org/entity/Q36368577

description

2000 nî lūn-bûn

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2000年の論文

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2000年学术文章

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2000年学术文章

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2000年学术文章

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2000年学术文章

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2000年学术文章

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2000年學術文章

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2000年學術文章

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2000年學術文章

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name

Initiation of apoptosis by gra ...... B-mediated caspase activation.

@ast

Initiation of apoptosis by gra ...... B-mediated caspase activation.

@en

type

label

Initiation of apoptosis by gra ...... B-mediated caspase activation.

@ast

Initiation of apoptosis by gra ...... B-mediated caspase activation.

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prefLabel

Initiation of apoptosis by gra ...... B-mediated caspase activation.

@ast

Initiation of apoptosis by gra ...... B-mediated caspase activation.

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JEM.192.10.1403

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Journal of Experimental Medicine

P1476

Initiation of apoptosis by gra ...... B-mediated caspase activation

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P2093

A A Ruefli

http://www.w3.org/2001/XMLSchema#string

J E Davis

http://www.w3.org/2001/XMLSchema#string

K A Browne

http://www.w3.org/2001/XMLSchema#string

K Sedelies

http://www.w3.org/2001/XMLSchema#string

M Cancilla

http://www.w3.org/2001/XMLSchema#string

V R Sutton

http://www.w3.org/2001/XMLSchema#string

P2860

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

BID: a novel BH3 domain-only death agonist

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

P304

1403-1414

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10.1084/JEM.192.10.1403

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10

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192

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Ricky W Johnstone

Joseph A Trapani

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2000-11-01T00:00:00Z

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12241559

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11085743

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apoptotic process

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2193191

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