Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms. - Wikidata - awgldk - TriplyDB

Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms.

Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms.

http://www.wikidata.org/entity/Q36368907

about

Vav1: A Dr. Jekyll and Mr. Hyde protein--good for the hematopoietic system, bad for cancer Vav family exchange factors: an integrated regulatory and functional view Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture.Expression of a Chimeric Antigen Receptor in Multiple Leukocyte Lineages in Transgenic Mice Myosin IIA associates with NK cell lytic granules to enable their interaction with F-actin and function at the immunological synapse.Transience in polarization of cytolytic effectors is required for efficient killing and controlled by Cdc42 Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase The role of HLA-G in immunity and hematopoiesis.Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors.Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production.Natural killer cell activation in mice and men: different triggers for similar weapons?Imaging immune surveillance by T cells and NK cells.Regulation of lymphocyte-mediated killing by GTP-binding proteins.Vav1 dephosphorylation by the tyrosine phosphatase SHP-1 as a mechanism for inhibition of cellular cytotoxicity.Vav1 acidic region tyrosine 174 is required for the formation of T cell receptor-induced microclusters and is essential in T cell development and activation Activation of natural killer cells: underlying molecular mechanisms revealed.Vav1 phosphorylation is induced by beta2 integrin engagement on natural killer cells upstream of actin cytoskeleton and lipid raft reorganization.Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells.Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells.Signaling for synergistic activation of natural killer cells.Dissecting natural killer cell activation pathways through analysis of genetic mutations in human and mouse.NK cell-activating receptors require PKC-theta for sustained signaling, transcriptional activation, and IFN-gamma secretion.β2 integrin induces TCRζ-Syk-phospholipase C-γ phosphorylation and paxillin-dependent granule polarization in human NK cells Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.Controlling natural killer cell responses: integration of signals for activation and inhibition.Differential modulating effect of natural killer (NK) T cells on interferon-γ production and cytotoxic function of NK cells and its relationship with NK subsets in Chlamydia muridarum infection.Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry.IFN-gamma production and degranulation are differentially regulated in response to stimulation in murine natural killer cells.The Effects of Artemisinin on the Cytolytic Activity of Natural Killer (NK) Cells Cytosolic PLA2 is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15.p66Shc regulates vesicle-mediated secretion in mast cells by affecting F-actin dynamics.NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases.ADAPted secretion of cytokines in NK cells.

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P2860

Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms.

http://www.wikidata.org/entity/Q36368907

description

2001 nî lūn-bûn

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2001年の論文

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年学术文章

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2001年學術文章

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2001年學術文章

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2001年學術文章

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Functional dichotomy in natura ...... t and -independent mechanisms.

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Functional dichotomy in natura ...... t and -independent mechanisms.

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type

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Functional dichotomy in natura ...... t and -independent mechanisms.

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Functional dichotomy in natura ...... t and -independent mechanisms.

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Functional dichotomy in natura ...... t and -independent mechanisms.

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Functional dichotomy in natura ...... t and -independent mechanisms.

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JEM.193.12.1413

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Journal of Experimental Medicine

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Functional dichotomy in natura ...... t and -independent mechanisms.

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P2093

E Rosmaraki

http://www.w3.org/2001/XMLSchema#string

J P Di Santo

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L Vanes

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S Bregenholt

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S I Samson

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V Di Bartolo

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P2860

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells

Deficient peptide loading and MHC class II endosomal sorting in a human genetic immunodeficiency disease: the Chediak-Higashi syndrome

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells

Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

Vav in natural killer cells is tyrosine phosphorylated upon cross-linking of Fc gamma RIIIA and is constitutively associated with a serine/threonine kinase

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

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1413-1424

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10.1084/JEM.193.12.1413

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12

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193

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Francesco Colucci

Victor Tybulewicz

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2001-06-01T00:00:00Z

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11927286

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11413196

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2193296

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