Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors. - Wikidata - awgldk - TriplyDB

Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors.

Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors.

http://www.wikidata.org/entity/Q34345732

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CD2 promotes human natural killer cell membrane nanotube formation The X-linked lymphoproliferative disease gene product SAP associates with PAK-interacting exchange factor and participates in T cell activation Structure of Natural Killer Receptor 2B4 Bound to CD48 Reveals Basis for Heterophilic Recognition in Signaling Lymphocyte Activation Molecule Family Fine specificity and molecular competition in SLAM family receptor signalling Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptor Up on the tightrope: natural killer cell activation and inhibition Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity.High expression of CD244 and SAP regulated CD8 T cell responses of patients with HTLV-I associated neurologic disease NK cell cytotoxicity mediated by 2B4 and NTB-A is dependent on SAP acting downstream of receptor phosphorylation.Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84.Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells.2B4 Is Dispensable for T-Dependent B Cell Immune Responses, but Its Deficiency Leads to Enhanced T-Independent Responses Due to an Increase in Peritoneal Cavity B1b Cells.SLAM Family Receptors Regulate Immunity with and without SAP-related Adaptors Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion Primary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis.Molecular and cellular pathogenesis of X-linked lymphoproliferative disease.Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation.Regulation of natural cytotoxicity by the adaptor SAP and the Src-related kinase Fyn.Immune regulation by SLAM family receptors and SAP-related adaptors.Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells.NK cell regulation by SLAM family receptors and SAP-related adapters.Activation, coactivation, and costimulation of resting human natural killer cells Dissecting natural killer cell activation pathways through analysis of genetic mutations in human and mouse.The role of SLAM family receptors in immune cell signaling.Requirement and redundancy of the Src family kinases Fyn and Lyn in perforin-dependent killing of Cryptococcus neoformans by NK cells The adaptor molecule signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is essential in mechanisms involving the Fyn tyrosine kinase for induction and progression of collagen-induced arthritis.Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cells EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization.Pediatric hemophagocytic syndromes: a diagnostic and therapeutic challenge The role of SAP and SLAM family molecules in the humoral immune response.The natural killer cell cytotoxic function is modulated by HIV-1 accessory proteins.2B4 (CD244) is involved in eosinophil adhesion and chemotaxis, and its surface expression is increased in allergic rhinitis after challenge.2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis.CD48 on blood leukocytes and in serum of asthma patients varies with severity.Dok-1 and Dok-2 Regulate the Formation of Memory CD8+ T Cells.Inhibition and activation by CD244 depends on CD2 and phospholipase C-gamma1 Natural killer cells and tumor metastasis.

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Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors.

http://www.wikidata.org/entity/Q34345732

description

2004 nî lūn-bûn

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2004年の論文

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Molecular dissection of 2B4 si ...... ion by SLAM-related receptors.

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Molecular dissection of 2B4 si ...... ion by SLAM-related receptors.

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Molecular dissection of 2B4 si ...... ion by SLAM-related receptors.

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Molecular dissection of 2B4 si ...... ion by SLAM-related receptors.

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Molecular dissection of 2B4 si ...... ion by SLAM-related receptors.

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Molecular dissection of 2B4 si ...... ion by SLAM-related receptors.

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Molecular dissection of 2B4 si ...... ion by SLAM-related receptors.

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Molecular dissection of 2B4 si ...... ion by SLAM-related receptors.

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Molecular dissection of 2B4 si ...... ion by SLAM-related receptors.

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MCB.24.12.5144-5156.2004

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Molecular and Cellular Biology

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Molecular dissection of 2B4 si ...... ion by SLAM-related receptors.

@en

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Ala Aoukaty

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André Veillette

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Francis Relouzat

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Riyan Chen

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P2860

The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP

SAP couples Fyn to SLAM immune receptors

Identification of a novel signal transduction surface molecule on human cytotoxic lymphocytes

2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48

Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome

NTB-A [correction of GNTB-A], a novel SH2D1A-associated surface molecule contributing to the inability of natural killer cells to kill Epstein-Barr virus-infected B cells in X-linked lymphoproliferative disease

X-linked lymphoproliferative disease. 2B4 molecules displaying inhibitory rather than activating function are responsible for the inability of natural killer cells to kill Epstein-Barr virus-infected cells

Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A

NK cell inhibitory receptors prevent tyrosine phosphorylation of the activation receptor 2B4 (CD244)

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5144-5156

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10.1128/MCB.24.12.5144-5156.2004

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Romain Roncagalli

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8536598

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