The mu switch region tandem repeats are important, but not required, for antibody class switch recombination.
about
Internal IgH class switch region deletions are position-independent and enhanced by AID expressionMutations, kataegis and translocations in B cells: understanding AID promiscuous activityShifts in targeting of class switch recombination sites in mice that lack mu switch region tandem repeats or Msh2Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctionsAID and Apobec3G haphazard deamination and mutational diversityPremature replacement of mu with alpha immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturation.Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions.Influence of switch region length on immunoglobulin class switch recombination.3D trajectories adopted by coding and regulatory DNA elements: first-passage times for genomic interactions.Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.AID and somatic hypermutation.Linking class-switch recombination with somatic hypermutation.Downstream boundary of chromosomal R-loops at murine switch regions: implications for the mechanism of class switch recombination.Mechanism and regulation of class switch recombinationAID to overcome the limitations of genomic information by introducing somatic DNA alterations.Accessibility control and machinery of immunoglobulin class switch recombination.Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination.Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch regionMice lacking Sμ tandem repeats maintain RNA polymerase patterns but exhibit histone modification pattern shifts linked to class switch site locations.Three-dimensional architecture of the IgH locus facilitates class switch recombination.Dependence of antibody gene diversification on uracil excision.Mapping of a functional recombination motif that defines isotype specificity for mu-->gamma3 switch recombination implicates NF-kappaB p50 as the isotype-specific switching factorInterplay between Target Sequences and Repair Pathways Determines Distinct Outcomes of AID-Initiated LesionsTwo new isotype-specific switching activities detected for Ig class switching.Sgamma3 switch sequences function in place of endogenous Sgamma1 to mediate antibody class switchingClass switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats.Reassessment of the role of Mut S homolog 5 in Ig class switch recombination shows lack of involvement in cis- and trans-switching.S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase.Switch region identity plays an important role in Ig class switch recombination.Polyclonal hyper-IgE mouse model reveals mechanistic insights into antibody class switch recombinationS region sequence, RNA polymerase II, and histone modifications create chromatin accessibility during class switch recombinationPost-translational regulation of activation-induced cytidine deaminase.AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination.Regulating infidelity: RNA-mediated recruitment of AID to DNA during class switch recombinationThe role of activation-induced deaminase in antibody diversification and genomic instability.A transcriptional serenAID: the role of noncoding RNAs in class switch recombination.14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination.Membrane immunoglobulin expressed by retroviral vector gene transfer mimics partial function of the B-cell receptor in vivo.The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- miceAID: a very old motif newly recognized.
P2860
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P2860
The mu switch region tandem repeats are important, but not required, for antibody class switch recombination.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
The mu switch region tandem re ...... dy class switch recombination.
@ast
The mu switch region tandem re ...... dy class switch recombination.
@en
type
label
The mu switch region tandem re ...... dy class switch recombination.
@ast
The mu switch region tandem re ...... dy class switch recombination.
@en
prefLabel
The mu switch region tandem re ...... dy class switch recombination.
@ast
The mu switch region tandem re ...... dy class switch recombination.
@en
P2093
P2860
P356
P1476
The mu switch region tandem re ...... dy class switch recombination.
@en
P2093
C E Schrader
J Stavnezer
P2860
P304
P356
10.1084/JEM.193.2.159
P407
P577
2001-01-01T00:00:00Z