Downstream boundary of chromosomal R-loops at murine switch regions: implications for the mechanism of class switch recombination.
about
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substratesNew insights into repeat instability: role of RNA•DNA hybridsEndonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regionsG-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptomeTranscription-associated R-loop formation across the human FMR1 CGG-repeat regionAID and somatic hypermutation.R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters.Overlapping activation-induced cytidine deaminase hotspot motifs in Ig class-switch recombination.R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome.R-loop-mediated genomic instability is caused by impairment of replication fork progressionComplexities due to single-stranded RNA during antibody detection of genomic rna:dna hybrids.Effect of CpG dinucleotides within IgH switch region repeats on immunoglobulin class switch recombination.Sequence dependence of chromosomal R-loops at the immunoglobulin heavy-chain Smu class switch regionA persistent RNA.DNA hybrid formed by transcription of the Friedreich ataxia triplet repeat in live bacteria, and by T7 RNAP in vitroThe repetitive portion of the Xenopus IgH Mu switch region mediates orientation-dependent class switch recombinationSingle-stranded DNA structure and positional context of the target cytidine determine the enzymatic efficiency of AID.GC skew is a conserved property of unmethylated CpG island promoters across vertebratesTranscription induces strand-specific mutations at the 5' end of human genes.Restricting activation-induced cytidine deaminase tumorigenic activity in B lymphocytes.AID: a riddle wrapped in a mystery inside an enigma.A transcriptional serenAID: the role of noncoding RNAs in class switch recombination.The role of G-density in switch region repeats for immunoglobulin class switch recombination.The strength of an Ig switch region is determined by its ability to drive R loop formation and its number of WGCW sites.Nascent Connections: R-Loops and Chromatin Patterning.Mechanism of R-loop formation at immunoglobulin class switch sequences.AID associates with single-stranded DNA with high affinity and a long complex half-life in a sequence-independent manner.The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- miceSense transcription through the S region is essential for immunoglobulin class switch recombination.Competition between the RNA transcript and the nontemplate DNA strand during R-loop formation in vitro: a nick can serve as a strong R-loop initiation site.Hypernegative supercoiling inhibits growth by causing RNA degradation.Relationships between the winding angle, the characteristic radius, and the torque for a long polymer chain wound around a cylinder: implications for RNA winding around DNA during transcription.A novel mode for transcription inhibition mediated by PNA-induced R-loops with a model in vitro system.
P2860
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P2860
Downstream boundary of chromosomal R-loops at murine switch regions: implications for the mechanism of class switch recombination.
description
2006 nî lūn-bûn
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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name
Downstream boundary of chromos ...... of class switch recombination.
@ast
Downstream boundary of chromos ...... of class switch recombination.
@en
Downstream boundary of chromos ...... of class switch recombination.
@nl
type
label
Downstream boundary of chromos ...... of class switch recombination.
@ast
Downstream boundary of chromos ...... of class switch recombination.
@en
Downstream boundary of chromos ...... of class switch recombination.
@nl
prefLabel
Downstream boundary of chromos ...... of class switch recombination.
@ast
Downstream boundary of chromos ...... of class switch recombination.
@en
Downstream boundary of chromos ...... of class switch recombination.
@nl
P2093
P2860
P356
P1476
Downstream boundary of chromos ...... of class switch recombination.
@en
P2093
Chih-Lin Hsieh
Feng-Ting Huang
Michael R Lieber
P2860
P304
P356
10.1073/PNAS.0506548103
P407
P577
2006-03-17T00:00:00Z