A new rodent model to assess blood stage immunity to the Plasmodium falciparum antigen merozoite surface protein 119 reveals a protective role for invasion inhibitory antibodies
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Transgenic rodent Plasmodium berghei parasites as tools for assessment of functional immunogenicity and optimization of human malaria vaccinesA newly discovered protein export machine in malaria parasitesIdentification and characterization of a novel Plasmodium falciparum merozoite apical protein involved in erythrocyte binding and invasionThe machinery underlying malaria parasite virulence is conserved between rodent and human malaria parasitesThe structure of Plasmodium yoelii merozoite surface protein 119, antibody specificity and implications for malaria vaccine designZIPCO, a putative metal ion transporter, is crucial for Plasmodium liver-stage developmentPlasmodium falciparum PF10_0164 (ETRAMP10.3) is an essential parasitophorous vacuole and exported protein in blood stagesGenetic linkage of autologous T cell epitopes in a chimeric recombinant construct improves anti-parasite and anti-disease protective effect of a malaria vaccine candidateThe Plasmodium rhoptry associated protein complex is important for parasitophorous vacuole membrane structure and intraerythrocytic parasite growthPTEX is an essential nexus for protein export in malaria parasitesPlasmodium falciparum merozoite surface protein 8 is a ring-stage membrane protein that localizes to the parasitophorous vacuole of infected erythrocytes.The importance of human FcgammaRI in mediating protection to malaria.Long-term clinical protection from falciparum malaria is strongly associated with IgG3 antibodies to merozoite surface protein 3.Phase I trial of an alhydrogel adjuvanted hepatitis B core virus-like particle containing epitopes of Plasmodium falciparum circumsporozoite protein.Construction of transgenic Plasmodium berghei as a model for evaluation of blood-stage vaccine candidate of Plasmodium falciparum chimeric protein 2.9.Malaria vaccines: where next?The dichotomy (generation of MAbs with functional heterogeneity) in antimalarial immune response in vaccinated/protected mice: a new concept in our understanding of the protective immune mechanisms in malaria.Chloroplast-derived vaccine antigens confer dual immunity against cholera and malaria by oral or injectable delivery.Growth-inhibitory antibodies are not necessary for protective immunity to malaria infection.Baculovirus-based nasal drop vaccine confers complete protection against malaria by natural boosting of vaccine-induced antibodies in miceThe Plasmodium falciparum merozoite surface protein-1 19 KD antibody response in the Peruvian Amazon predominantly targets the non-allele specific, shared sites of this antigen.Plasmodium berghei circumvents immune responses induced by merozoite surface protein 1- and apical membrane antigen 1-based vaccines.Minimal role for the circumsporozoite protein in the induction of sterile immunity by vaccination with live rodent malaria sporozoitesFine specificity of anti-MSP119 antibodies and multiplicity of Plasmodium falciparum merozoite surface protein 1 types in individuals in Nigeria with sub-microscopic infection.Development and optimization of high-throughput methods to measure Plasmodium falciparum-specific growth inhibitory antibodies.A set of glycosylphosphatidyl inositol-anchored membrane proteins of Plasmodium falciparum is refractory to genetic deletionIn Vivo Function of PTEX88 in Malaria Parasite Sequestration and Virulence.Kinetics of humoral and memory B cell response induced by the Plasmodium falciparum 19-kilodalton merozoite surface protein 1 in micePlasmodium falciparum: immunization with MSP1-42 induced non-inhibitory antibodies that have no blocking activities but enhanced the potency of inhibitory anti-MSP1-42 antibodies.Plasmodium falciparum malaria in the Peruvian Amazon, a region of low transmission, is associated with immunologic memory.Plasmodium falciparum line-dependent association of in vitro growth-inhibitory activity and risk of malaria.Tailoring subunit vaccine immunogenicity: maximizing antibody and T cell responses by using combinations of adenovirus, poxvirus and protein-adjuvant vaccines against Plasmodium falciparum MSP1.Results from tandem Phase 1 studies evaluating the safety, reactogenicity and immunogenicity of the vaccine candidate antigen Plasmodium falciparum FVO merozoite surface protein-1 (MSP1(42)) administered intramuscularly with adjuvant system AS01.The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment.Development of a Plasmodium berghei transgenic parasite expressing the full-length Plasmodium vivax circumsporozoite VK247 protein for testing vaccine efficacy in a murine modelAntibody response dynamics to the Plasmodium falciparum conserved vaccine candidate antigen, merozoite surface protein-1 C-terminal 19kD (MSP1-19kD), in Peruvians exposed to hypoendemic malaria transmission.Development of a chimeric Plasmodium berghei strain expressing the repeat region of the P. vivax circumsporozoite protein for in vivo evaluation of vaccine efficacy.What can transgenic parasites tell us about the development of Plasmodium-specific immune responses?A key role for Plasmodium subtilisin-like SUB1 protease in egress of malaria parasites from host hepatocytes.The fine specificity, but not the invasion inhibitory activity, of 19-kilodalton merozoite surface protein 1-specific antibodies is associated with resistance to malarial parasitemia in a cross-sectional survey in The Gambia.
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A new rodent model to assess blood stage immunity to the Plasmodium falciparum antigen merozoite surface protein 119 reveals a protective role for invasion inhibitory antibodies
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
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2003年學術文章
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2003年學術文章
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name
A new rodent model to assess b ...... invasion inhibitory antibodies
@ast
A new rodent model to assess b ...... invasion inhibitory antibodies
@en
type
label
A new rodent model to assess b ...... invasion inhibitory antibodies
@ast
A new rodent model to assess b ...... invasion inhibitory antibodies
@en
prefLabel
A new rodent model to assess b ...... invasion inhibitory antibodies
@ast
A new rodent model to assess b ...... invasion inhibitory antibodies
@en
P2860
P50
P356
P1476
A new rodent model to assess b ...... invasion inhibitory antibodies
@en
P2093
Damien R Drew
Rebecca A O'Donnell
P2860
P304
P356
10.1084/JEM.20030085
P407
P577
2003-09-08T00:00:00Z