Phosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection.

Phosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection.

Item
http://www.wikidata.org/entity/Q36372744
SAMHD1-mediated HIV-1 restriction in cells does not involve ribonuclease activityExogenous expression of SAMHD1 inhibits proliferation and induces apoptosis in cutaneous T-cell lymphoma-derived HuT78 cells.SAMHD1 controls cell cycle status, apoptosis and HIV-1 infection in monocytic THP-1 cells.A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse.Human Primary Macrophages Derived In Vitro from Circulating Monocytes Comprise Adherent and Non-Adherent Subsets with Differential Expression of Siglec-1 and CD4 and Permissiveness to HIV-1 Infection.The SAM domain of mouse SAMHD1 is critical for its activation and regulation.A Cyclin-binding Motif in Human SAMHD1 Is Required for Its HIV-1 Restriction, dNTPase Activity, Tetramer Formation, and Efficient Phosphorylation.SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways.Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit.SAMHD1 Impairs HIV-1 Gene Expression and Negatively Modulates Reactivation of Viral Latency in CD4+ T-cells.SAMHD1 modulates in vitro proliferation of acute myeloid leukemia-derived THP-1 cells through the PI3K-Akt-p27 axis
P2860

Phosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection.

Item
http://www.wikidata.org/entity/Q36372744
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
Phosphorylation of mouse SAMHD ...... rine leukemia virus infection.
@ast
Phosphorylation of mouse SAMHD ...... rine leukemia virus infection.
@en
type
label
Phosphorylation of mouse SAMHD ...... rine leukemia virus infection.
@ast
Phosphorylation of mouse SAMHD ...... rine leukemia virus infection.
@en
prefLabel
Phosphorylation of mouse SAMHD ...... rine leukemia virus infection.
@ast
Phosphorylation of mouse SAMHD ...... rine leukemia virus infection.
@en
P1433
P1476
P2093
P2860
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P356
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P478
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P577
P698
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P932
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P1433
P1476
Phosphorylation of mouse SAMHD ...... urine leukemia virus infection
@en
P2093
P2860
P304
P31
P356
10.1016/J.VIROL.2015.10.024
P407
P478
P50
P577
P698
P921
P932