The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors.
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Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs.Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus.Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice.Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation.Suvorexant for the treatment of insomnia.A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effectsGenes and primary headaches: discovering new potential therapeutic targets.Involvement of the orexin/hypocretin system in the pharmacological effects induced by Δ(9) -tetrahydrocannabinolOrexin receptor antagonists as therapeutic agents for insomniaDiscovery and development of orexin receptor antagonists as therapeutics for insomnia.Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism.Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders.Sites of action of sleep and wake drugs: insights from model organisms.Small-molecule antagonists of the orexin receptors.Role of orexin in respiratory and sleep homeostasis during upper airway obstruction in rats.Role of orexin-A in the ventrolateral preoptic area on components of total energy expenditure.Orexin OX2 Receptor Antagonists as Sleep Aids.Locus Coeruleus and Tuberomammillary Nuclei Ablations Attenuate Hypocretin/Orexin Antagonist-Mediated REM Sleep.Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors.Distinct effects of IPSU and suvorexant on mouse sleep architecture.OREXIN 1 AND 2 RECEPTOR INVOLVEMENT IN CO2 -INDUCED PANIC-ASSOCIATED BEHAVIOR AND AUTONOMIC RESPONSES.The dual orexin receptor antagonist, DORA-22, lowers histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine.The Role of Orexins/Hypocretins in Alcohol Use and Abuse.Diurnal inhibition of NMDA-EPSCs at rat hippocampal mossy fibre synapses through orexin-2 receptors.Optogenetic identification of hypothalamic orexin neuron projections to paraventricular spinally projecting neurons.The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases.Orexin Receptor Antagonists
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P2860
The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
@zh-hant
name
The dual orexin receptor antag ...... y blocking orexin 2 receptors.
@ast
The dual orexin receptor antag ...... y blocking orexin 2 receptors.
@en
type
label
The dual orexin receptor antag ...... y blocking orexin 2 receptors.
@ast
The dual orexin receptor antag ...... y blocking orexin 2 receptors.
@en
prefLabel
The dual orexin receptor antag ...... y blocking orexin 2 receptors.
@ast
The dual orexin receptor antag ...... y blocking orexin 2 receptors.
@en
P2093
P2860
P50
P356
P1433
P1476
The dual orexin receptor antag ...... y blocking orexin 2 receptors.
@en
P2093
Dorothee Abramowski
Edi Schuepbach
Géraldine M Mang
Hugo Bürki
Stefan Imobersteg
Thomas Dürst
P2860
P304
P356
10.5665/SLEEP.2232
P577
2012-12-01T00:00:00Z