Constitutive expression of interleukin (IL)-4 in vivo causes autoimmune-type disorders in mice.
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Linking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosusIncreased levels of alternatively spliced interleukin 4 (IL-4delta2) transcripts in peripheral blood mononuclear cells from patients with systemic sclerosisInducible resistance to Fas-mediated apoptosis in B cells.Mechanisms of self-tolerance and autoimmunity: from whole-animal phenotypes to molecular pathways.Splenectomy and sepsis: the role of the spleen in the immune-mediated bacterial clearance.γδ T cells affect IL-4 production and B-cell toleranceAccelerated pathological and clinical nephritis in systemic lupus erythematosus-prone New Zealand Mixed 2328 mice doubly deficient in TNF receptor 1 and TNF receptor 2 via a Th17-associated pathwayReducing FLI1 levels in the MRL/lpr lupus mouse model impacts T cell function by modulating glycosphingolipid metabolismDeletion of IL-4 receptor alpha on dendritic cells renders BALB/c mice hypersusceptible to Leishmania major infection.B cell inhibitory receptors and autoimmunity.Dendritic cells under investigation in autoimmune disease.Thymic stromal lymphopoietin (TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4+ T cells and IL-4.Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling.Interleukin 4 reduces expression of inhibitory receptors on B cells and abolishes CD22 and Fc gamma RII-mediated B cell suppression.Interferon gamma enhances both in vitro and in vivo priming of CD4+ T cells for IL-4 production.Repression of B7.2 on self-reactive B cells is essential to prevent proliferation and allow Fas-mediated deletion by CD4(+) T cellsDifferential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis.Impaired Memory in OT-II Transgenic Mice Is Associated with Decreased Adult Hippocampal Neurogenesis Possibly Induced by Alteration in Th2 Cytokine Levels.Receptor crosstalk: reprogramming B cell receptor signalling to an alternate pathway results in expression and secretion of the autoimmunity-associated cytokine, osteopontinRestricted CD4+ T cell receptor repertoire impairs cognitive function via alteration of Th2 cytokine levels.Anti-IL-4 treatment prevents dermal collagen deposition in the tight-skin mouse model of scleroderma.Th1 (IL-2, interferon-gamma (IFN-gamma)) and Th2 (IL-10, IL-4) cytokine production by peripheral blood mononuclear cells (PBMC) from patients with systemic lupus erythematosus (SLE).Autoreactive murine Th1 and Th2 cells kill syngeneic macrophages and induce autoantibodies.Effector and predisposing genes in murine lupus.Interleukin-4 Supports the Suppressive Immune Responses Elicited by Regulatory T Cells.B cell-derived IL-4 acts on podocytes to induce proteinuria and foot process effacement.Naturally activated CD4+ T cells are highly enriched for cytokine-producing cells.Alterations in T-lymphocyte sub-set profiles and cytokine secretion by PBMC of systemic lupus erythematosus patients upon in vitro exposure to organochlorine pesticides.
P2860
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P2860
Constitutive expression of interleukin (IL)-4 in vivo causes autoimmune-type disorders in mice.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Constitutive expression of int ...... immune-type disorders in mice.
@ast
Constitutive expression of int ...... immune-type disorders in mice.
@en
type
label
Constitutive expression of int ...... immune-type disorders in mice.
@ast
Constitutive expression of int ...... immune-type disorders in mice.
@en
prefLabel
Constitutive expression of int ...... immune-type disorders in mice.
@ast
Constitutive expression of int ...... immune-type disorders in mice.
@en
P2093
P2860
P356
P1476
Constitutive expression of int ...... immune-type disorders in mice.
@en
P2093
P2860
P304
P356
10.1084/JEM.185.2.329
P407
P577
1997-01-01T00:00:00Z