Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice.
about
Nuclear and mitochondrial interaction involving mt-Nd2 leads to increased mitochondrial reactive oxygen species productionPerforin-independent CD8(+) T-cell-mediated cytotoxicity of alveolar epithelial cells is preferentially mediated by tumor necrosis factor-alpha: relative insensitivity to Fas ligand.Dissecting the role of CD4+ T cells in autoimmune diabetes through the use of TCR transgenic mice.Transgenes and knockout mutations in animal models of type 1 diabetes and multiple sclerosis.Different modes of pathogenesis in T-cell-dependent autoimmunity: clues from two TCR transgenic systems.Regulation of Fas-mediated apoptosis in CD2-fas transgenic mice.Apoptosis and CD95 ligand in immune privileged sites.Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic miceChanges in function of antigen-specific lymphocytes correlating with progression towards diabetes in a transgenic model.IL-1alpha, IL-1beta, and IFN-gamma mark beta cells for Fas-dependent destruction by diabetogenic CD4(+) T lymphocytesCyclin D3 promotes pancreatic β-cell fitness and viability in a cell cycle-independent manner and is targeted in autoimmune diabetes.Novel experimental strategies to prevent the development of type 1 diabetes mellitus.Contribution of Fas to diabetes development.Blocking Fas ligand on leukocytes attenuates kidney ischemia-reperfusion injury.Effect of transgenic overexpression of FLIP on lymphocytes on development and resolution of experimental autoimmune thyroiditisApoptosis in autoimmune diabetes: the fate of beta-cells in the cleft between life and death.NF-kappa B prevents beta cell death and autoimmune diabetes in NOD miceMurine FLIP transgene expressed on thyroid epithelial cells promotes resolution of granulomatous experimental autoimmune thyroiditis in DBA/1 mice.Protection from autoimmune diabetes and T-cell lymphoproliferation induced by FasL mutation are differentially regulated and can be uncoupled pharmacologicallyThe role of macrophages in T cell-mediated autoimmune diabetes in nonobese diabetic mice.In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha.Dual role for Fas ligand in the initiation of and recovery from experimental allergic encephalomyelitis.Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an inhibitor of autoimmune inflammation and cell cycle progression.Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription.Transgenic expression of decoy receptor 3 protects islets from spontaneous and chemical-induced autoimmune destruction in nonobese diabetic mice.Pancreatic beta cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetesDichotomy between naïve and memory CD4(+) T cell responses to Fas engagementBeta-cell apoptosis in an accelerated model of autoimmune diabetesHuman β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity.Cultured murine thyroid epithelial cells expressing transgenic Fas-associated death domain-like interleukin-1beta converting enzyme inhibitory protein are protected from fas-mediated apoptosis.Mechanisms of beta cell death in diabetes: a minor role for CD95.The vicious cycle of apoptotic beta-cell death in type 1 diabetes.A mouse CD8 T cell-mediated acute autoimmune diabetes independent of the perforin and Fas cytotoxic pathways: possible role of membrane TNF.Fas-mediated apoptosis in clinical remissions of relapsing experimental autoimmune encephalomyelitis.Proinflammatory consequences of transgenic fas ligand expression in the heart.In vivo diabetogenic action of CD4+ T lymphocytes requires Fas expression and is independent of IL-1 and IL-18.A targeted DNA vaccine encoding fas ligand defines its dual role in the regulation of experimental autoimmune encephalomyelitisExecutioners of apoptosis in pancreatic {beta}-cells: not just for cell death.Immunological pathways to β-cell damage in Type 1 diabetes.FADD phosphorylation impaired islet morphology and function.
P2860
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P2860
Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice.
@ast
Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice.
@en
type
label
Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice.
@ast
Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice.
@en
prefLabel
Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice.
@ast
Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice.
@en
P2093
P2860
P356
P1476
Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice.
@en
P2093
H Iwahashi
H Nakajima
J Miyagawa
K Yamamoto
M Moriwaki
P2860
P304
P356
10.1084/JEM.186.4.613
P407
P577
1997-08-01T00:00:00Z