ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection.
about
The response to and repair of RAG-mediated DNA double-strand breaksATM-mediated transcriptional and developmental responses to gamma-rays in ArabidopsisMultiple autophosphorylation sites are dispensable for murine ATM activation in vivoA new ataxia-telangiectasia mutation in an 11-year-old femaleMultifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenanceATM stabilizes DNA double-strand-break complexes during V(D)J recombination.Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation.ATM influences the efficiency of TCRβ rearrangement, subsequent TCRβ-dependent T cell development, and generation of the pre-selection TCRβ CDR3 repertoire.Tug of war between survival and death: exploring ATM function in cancer.Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombinationMicroRNA regulation of molecular networks mapped by global microRNA, mRNA, and protein expression in activated T lymphocytesATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor alpha locus coding end breaks.ATM facilitates mouse gammaherpesvirus reactivation from myeloid cells during chronic infection.Human T-lymphotropic virus type-1 p30 alters cell cycle G2 regulation of T lymphocytes to enhance cell survival.Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes.O6-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomasDeclining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations.Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG.Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytesDeficiency of the DNA repair enzyme ATM in rheumatoid arthritis.Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis.ATM kinase activity modulates ITCH E3-ubiquitin ligase activity.ATM kinase sustains HER2 tumorigenicity in breast cancer.Repair of chromosomal RAG-mediated DNA breaks by mutant RAG proteins lacking phosphatidylinositol 3-like kinase consensus phosphorylation sites.The cyclin-dependent kinase inhibitor 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole induces nongenotoxic, DNA replication-independent apoptosis of normal and leukemic cells, regardless of their p53 statusNOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy.Emerging therapeutic targets in myeloproliferative neoplasms and peripheral T-cell leukemia and lymphomas.Therapeutic potential of spleen tyrosine kinase inhibition for treating high-risk precursor B cell acute lymphoblastic leukemia.Atm reactivation reverses ataxia telangiectasia phenotypes in vivo.Developing T lymphocytes are uniquely sensitive to a lack of topoisomerase III alpha.Thymus and T-lymphocyte development: what is new in the 21st century?Patient with ataxia telangiectasia who developed acute myeloid leukemia
P2860
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P2860
ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
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2006年學術文章
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2006年學術文章
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name
ATM-dependent DNA damage surve ...... mogenesis: the DSB connection.
@ast
ATM-dependent DNA damage surve ...... mogenesis: the DSB connection.
@en
type
label
ATM-dependent DNA damage surve ...... mogenesis: the DSB connection.
@ast
ATM-dependent DNA damage surve ...... mogenesis: the DSB connection.
@en
prefLabel
ATM-dependent DNA damage surve ...... mogenesis: the DSB connection.
@ast
ATM-dependent DNA damage surve ...... mogenesis: the DSB connection.
@en
P2093
P2860
P1476
ATM-dependent DNA damage surve ...... mogenesis: the DSB connection.
@en
P2093
Cynthia J Guidos
Irina R Matei
Jayne S Danska
P2860
P304
P356
10.1111/J.0105-2896.2006.00361.X
P577
2006-02-01T00:00:00Z