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NMR Meets Tau: Insights into Its Function and PathologyConnecting the dots between tau dysfunction and neurodegenerationTPX2 Inhibits Eg5 by Interactions with Both Motor and Microtubule.Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase.Single-molecule tracking of tau reveals fast kiss-and-hop interaction with microtubules in living neuronsRoles of tau protein in health and disease.Kinesin's neck-linker determines its ability to navigate obstacles on the microtubule surfacePhosphoregulation of Tau modulates inhibition of kinesin-1 motility.Viscoelasticity of tau proteins leads to strain rate-dependent breaking of microtubules during axonal stretch injury: predictions from a mathematical model.The family-specific K-loop influences the microtubule on-rate but not the superprocessivity of kinesin-3 motors.Tau interconverts between diffusive and stable populations on the microtubule surface in an isoform and lattice specific manner.Mechanical Effects of Dynamic Binding between Tau Proteins on Microtubules during Axonal InjuryMobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant TauRole of tau in the spatial organization of axonal microtubules: keeping parallel microtubules evenly distributed despite macromolecular crowding.Interplay between velocity and travel distance of kinesin-based transport in the presence of tau.The influence of dynein processivity control, MAPs, and microtubule ends on directional movement of a localising mRNA.FRET and FRAP imaging: approaches to characterise tau and stathmin interactions with microtubules in cells.Transport and diffusion of Tau protein in neurons.Kinesin-1 motors can circumvent permanent roadblocks by side-shifting to neighboring protofilaments.Staging of cognitive deficits and neuropathological and ultrastructural changes in streptozotocin-induced rat model of Alzheimer's disease.A refined reaction-diffusion model of tau-microtubule dynamics and its application in FDAP analysis.Tau and neuron aging.Genetic defects in β-spectrin and tau sensitize C. elegans axons to movement-induced damage via torque-tension coupling.Oligomerization of the microtubule-associated protein tau is mediated by its N-terminal sequences: implications for normal and pathological tau action.Can numerical modeling help understand the fate of tau protein in the axon terminal?The +TIP coordinating protein EB1 is highly dynamic and diffusive on microtubules, sensitive to GTP analog, ionic strength, and EB1 concentration.Tau proteins in the temporal and frontal cortices in patients with vascular dementia.Atypical, non-standard functions of the microtubule associated Tau protein.Tau directs intracellular trafficking by regulating the forces exerted by kinesin and dynein teams.Acetylated Microtubules Are Preferentially Bundled Leading to Enhanced Kinesin-1 Motility.Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase.The axonal transport motor kinesin-2 navigates microtubule obstacles via protofilament switching.What mechanisms of tau protein transport could be responsible for the inverted tau concentration gradient in degenerating axons?Simulating tubulin-associated unit transport in an axon: using bootstrapping for estimating confidence intervals of best-fit parameter values obtained from indirect experimental data.How the formation of amyloid plaques and neurofibrillary tangles may be related: a mathematical modelling study.E-hooks provide guidance and a soft landing for the microtubule binding domain of dynein
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Tau protein diffuses along the microtubule lattice
@ast
Tau protein diffuses along the microtubule lattice
@en
type
label
Tau protein diffuses along the microtubule lattice
@ast
Tau protein diffuses along the microtubule lattice
@en
prefLabel
Tau protein diffuses along the microtubule lattice
@ast
Tau protein diffuses along the microtubule lattice
@en
P2093
P2860
P356
P1476
Tau protein diffuses along the microtubule lattice
@en
P2093
Avesta Jalal
Bernhard Brenner
Maike H Hinrichs
Satish Kumar
Tim Scholz
P2860
P304
38559-38568
P356
10.1074/JBC.M112.369785
P407
P577
2012-09-27T00:00:00Z