A nonmotor microtubule binding site in kinesin-5 is required for filament crosslinking and sliding - Wikidata - awgldk - TriplyDB

A nonmotor microtubule binding site in kinesin-5 is required for filament crosslinking and sliding

A nonmotor microtubule binding site in kinesin-5 is required for filament crosslinking and sliding

http://www.wikidata.org/entity/Q24608232

about

Kinesin-5: cross-bridging mechanism to targeted clinical therapy Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5 Microtubule redistribution in growth cones elicited by focal inactivation of kinesin-5 The bipolar assembly domain of the mitotic motor kinesin-5 TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle Putative biomarkers and targets of estrogen receptor negative human breast cancer Regulatory mechanisms that control mitotic kinesins Deletion of the Tail Domain of the Kinesin-5 Cin8 Affects Its Directionality TPX2 Inhibits Eg5 by Interactions with Both Motor and Microtubule.The crystal structure and biochemical characterization of Kif15: a bifunctional molecular motor involved in bipolar spindle formation and neuronal development Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family.Structural basis for the assembly of the mitotic motor Kinesin-5 into bipolar tetramers Motile properties of the bi-directional kinesin-5 Cin8 are affected by phosphorylation in its motor domain.A tethering mechanism controls the processivity and kinetochore-microtubule plus-end enrichment of the kinesin-8 Kif18A.Dynamic reorganization of Eg5 in the mammalian spindle throughout mitosis requires dynein and TPX2.The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle.Caenorhabditis elegans oocyte meiotic spindle pole assembly requires microtubule severing and the calponin homology domain protein ASPM-1.Opposite rheological properties of neuronal microcompartments predict axonal vulnerability in brain injury.Schizosaccharomyces pombe kinesin-5 switches direction using a steric blocking mechanism.The mitotic kinesin-14 KlpA contains a context-dependent directionality switch Regulation of Kif15 localization and motility by the C-terminus of TPX2 and microtubule dynamics.Asymmetric friction of nonmotor MAPs can lead to their directional motion in active microtubule networks.Mechanism and regulation of kinesin-5, an essential motor for the mitotic spindle.The family-specific K-loop influences the microtubule on-rate but not the superprocessivity of kinesin-3 motors.Structural maintenance of chromosome (SMC) proteins link microtubule stability to genome integrity.Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy.Analysis of tubulin alpha-1A/1B C-terminal tail post-translational poly-glutamylation reveals novel modification sites.Regulation of bi-directional movement of single kinesin-5 Cin8 molecules.Tau protein diffuses along the microtubule lattice A chimeric kinesin-1 head/kinesin-5 tail motor switches between diffusive and processive motility Metaphase Spindle Assembly.Bioimage informatics for understanding spatiotemporal dynamics of cellular processes.The molecular basis for kinesin functional specificity during mitosis.Intrinsic Disorder in the Kinesin Superfamily.Kif18A uses a microtubule binding site in the tail for plus-end localization and spindle length regulation.The mechanics of microtubule networks in cell division.Molecular mechanisms of kinesin-14 motors in spindle assembly and chromosome segregation.Directionality of individual kinesin-5 Cin8 motors is modulated by loop 8, ionic strength and microtubule geometry.Measuring Pushing and Braking Forces Generated by Ensembles of Kinesin-5 Crosslinking Two Microtubules.Examining the mechanism of action of a kinesin inhibitor using stable isotope labeled inhibitors for cross-linking (SILIC).

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A nonmotor microtubule binding site in kinesin-5 is required for filament crosslinking and sliding

http://www.wikidata.org/entity/Q24608232

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

A nonmotor microtubule binding ...... ament crosslinking and sliding

@ast

A nonmotor microtubule binding ...... ament crosslinking and sliding

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A nonmotor microtubule binding ...... ament crosslinking and sliding

@nl

type

label

A nonmotor microtubule binding ...... ament crosslinking and sliding

@ast

A nonmotor microtubule binding ...... ament crosslinking and sliding

@en

A nonmotor microtubule binding ...... ament crosslinking and sliding

@nl

prefLabel

A nonmotor microtubule binding ...... ament crosslinking and sliding

@ast

A nonmotor microtubule binding ...... ament crosslinking and sliding

@en

A nonmotor microtubule binding ...... ament crosslinking and sliding

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J.CUB.2010.12.038

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Current Biology

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A nonmotor microtubule binding ...... ament crosslinking and sliding

@en

P2093

Ge Yang

http://www.w3.org/2001/XMLSchema#string

Joshua S Weinger

http://www.w3.org/2001/XMLSchema#string

Minhua Qiu

http://www.w3.org/2001/XMLSchema#string

Tarun M Kapoor

http://www.w3.org/2001/XMLSchema#string

P2860

A bipolar kinesin

A "slow" homotetrameric kinesin-related motor protein purified from Drosophila embryos

Microtubule cross-linking triggers the directional motility of kinesin-5

Individual dimers of the mitotic kinesin motor Eg5 step processively and support substantial loads in vitro

The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5

The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends

Mitotic spindle organization by a plus-end-directed microtubule motor

Kinesin-1 heavy chain mediates microtubule sliding to drive changes in cell shape

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154-60

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scholarly article

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1410856

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10.1016/J.CUB.2010.12.038

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2

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21

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49757063

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21236672

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3049310

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