Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study.
about
Disc in flames: Roles of TNF-α and IL-1β in intervertebral disc degenerationRole of cytokines in intervertebral disc degeneration: pain and disc contentExpression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degenerationEmerging technologies for molecular therapy for intervertebral disk degenerationTranscriptional alteration of matrix-related gene expression in cultured human disc cells by nanoparticles of a bismethanophosphonate fullerene.Orthopedic gene therapy in 2008.Lentiviral shRNA silencing of CHOP inhibits apoptosis induced by cyclic stretch in rat annular cells and attenuates disc degeneration in the rats.Modic changes and interleukin 1 gene locus polymorphisms in occupational cohort of middle-aged men.Determination and comparison of specifics of nucleus pulposus cells of human intervertebral disc in alginate and chitosan-gelatin scaffolds.Effect of interleukin-1β treatment on co-cultures of human meniscus cells and bone marrow mesenchymal stromal cells.Inflammation in intervertebral disc degeneration and regenerationThe involvement of interleukin-1 and interleukin-4 in the response of human annulus fibrosus cells to cyclic tensile strain: an altered mechanotransduction pathway with degenerationInflammatory profiles in canine intervertebral disc degenerationInflammatory Kinetics and Efficacy of Anti-inflammatory Treatments on Human Nucleus Pulposus Cells.Genetic polymorphisms associated with intervertebral disc degeneration.Novel approaches for treating musculoskeletal diseases: molecular orthopedics and systems medicine.Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration.Update on the pathophysiology of degenerative disc disease and new developments in treatment strategiesAn in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue.Strategies for regeneration of the intervertebral disc.Gene therapy approach for disc degeneration and associated spinal disordersExpression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells.Progress and Prospects: genetic treatments for disorders of bones and joints.IAPP modulates cellular autophagy, apoptosis, and extracellular matrix metabolism in human intervertebral disc cells.Understanding the native nucleus pulposus cell phenotype has important implications for intervertebral disc regeneration strategies.Molecular and genetic advances in the regeneration of the intervertebral disc.Disc cell therapies: critical issues.Intervertebral disc regeneration: do nutrients lead the way?Molecular basis of intervertebral disc degeneration and herniations: what are the important translational questions?Using genes to facilitate the endogenous repair and regeneration of orthopaedic tissuesBiologic treatment of mild and moderate intervertebral disc degeneration.Impact of changes in extracellular matrix in the lumbar degenerative disc.Biological approaches to treating intervertebral disk degeneration: devising stem cell therapies.Intervertebral Disk Degeneration and Repair.The chemokine, CXCL16, and its receptor, CXCR6, are constitutively expressed in human annulus fibrosus and expression of CXCL16 is up-regulated by exposure to IL-1ß in vitro.Cell-based therapies for intervertebral disc and cartilage regeneration- Current concepts, parallels, and perspectives.Qualitative grading of disc degeneration by magnetic resonance in the lumbar and cervical spine: lack of correlation with histology in surgical cases.Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degenerationDifferential Characterization of Two Kinds of Stem Cells Isolated from Rabbit Nucleus Pulposus and Annulus Fibrosus.Development of an in vitro model to test the efficacy of novel therapies for IVD degeneration
P2860
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P2860
Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Interleukin-1 receptor antagon ...... raphic and gene therapy study.
@ast
Interleukin-1 receptor antagon ...... raphic and gene therapy study.
@en
type
label
Interleukin-1 receptor antagon ...... raphic and gene therapy study.
@ast
Interleukin-1 receptor antagon ...... raphic and gene therapy study.
@en
prefLabel
Interleukin-1 receptor antagon ...... raphic and gene therapy study.
@ast
Interleukin-1 receptor antagon ...... raphic and gene therapy study.
@en
P2093
P2860
P356
P1476
Interleukin-1 receptor antagon ...... raphic and gene therapy study.
@en
P2093
Anthony J Freemont
Christine L Le Maitre
Judith A Hoyland
P2860
P2888
P356
10.1186/AR2282
P577
2007-01-01T00:00:00Z
P5875
P6179
1004528208