Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer - Wikidata - awgldk - TriplyDB

Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer

Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer

http://www.wikidata.org/entity/Q36393103

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Regulation of TAZ in cancer The Changes of HIF-1α and VEGF Expression After TACE in Patients With Hepatocellular Carcinoma The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer Wnt-responsive cancer stem cells are located close to distorted blood vessels and not in hypoxic regions in a p53-null mouse model of human breast cancer.Sunitinib significantly suppresses the proliferation, migration, apoptosis resistance, tumor angiogenesis and growth of triple-negative breast cancers but increases breast cancer stem cells.Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway.Hallmarks of triple negative breast cancer emerging at last?The basal epithelial marker P-cadherin associates with breast cancer cell populations harboring a glycolytic and acid-resistant phenotype.The role of melanogenesis in regulation of melanoma behavior: melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways.Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA.A novel function of novobiocin: disrupting the interaction of HIF 1α and p300/CBP through direct binding to the HIF1α C-terminal activation domain.Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells Down-regulation of hypoxia-inducible factor-1 suppresses malignant biological behavior of triple-negative breast cancer cells.hypoxia-inducible factors activate CD133 promoter through ETS family transcription factors.Peritoneal milky spots serve as a hypoxic niche and favor gastric cancer stem/progenitor cell peritoneal dissemination through hypoxia-inducible factor 1α.Breast tumor kinase (Brk/PTK6) is a mediator of hypoxia-associated breast cancer progression.Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype.Hypoxia/HIF1α induces lapatinib resistance in ERBB2-positive breast cancer cells via regulation of DUSP2 MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis in basal breast cancers HIF targets in bone remodeling and metastatic disease.Differential HIF-1α and HIF-2α Expression in Mammary Epithelial Cells during Fat Pad Invasion, Lactation, and Involution.mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer.The CCL2 chemokine is a negative regulator of autophagy and necrosis in luminal B breast cancer cells Hypoxia-inducible factors in cancer stem cells and inflammation.The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages.Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α.HIF-1 at the crossroads of hypoxia, inflammation, and cancer.The hypoxic tumor microenvironment: A driving force for breast cancer progression.Distinct breast cancer stem/progenitor cell populations require either HIF1α or loss of PHD3 to expand under hypoxic conditions ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models.Cancer stem cells and chemoresistance: The smartest survives the raid The oncogene HER2/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance Do signal transduction cascades influence survival in triple-negative breast cancer? A preliminary study.A potential diagnostic marker for ovarian cancer: Involvement of the histone acetyltransferase, human males absent on the first.A hypoxic signature marks tumors formed by disseminated tumor cells in the BALB-neuT mammary cancer model.In triple negative breast tumor cells, PLC-β2 promotes the conversion of CD133high to CD133low phenotype and reduces the CD133-related invasiveness The quinoxaline di-N-oxide DCQ blocks breast cancer metastasis in vitro and in vivo by targeting the hypoxia inducible factor-1 pathway.Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer.Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells.

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Hypoxia-inducible factor 1α promotes primary tumor growth and tumor-initiating cell activity in breast cancer

http://www.wikidata.org/entity/Q36393103

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2012年学术文章

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2012年學術文章

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Hypoxia-inducible factor 1α pr ...... cell activity in breast cancer

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Breast Cancer Research

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Danielle L Peacock

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Debeshi Majumdar

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Jesse F Ingels

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Keisha D Smith

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Laura C Jensen

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Richard C Cushing

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Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model

Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers

Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases

Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis

Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype

CD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer

Differential impact of EGFR-targeted therapies on hypoxia responses: implications for treatment sensitivity in triple-negative metastatic breast cancer

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1

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