Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis.
about
The INT6 cancer gene and MEK signaling pathways converge during zebrafish developmentThe proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila.Identification of a putative protein profile associated with tamoxifen therapy resistance in breast cancer.Chondroitin sulfate proteoglycans: structure-function relationship with implication in neural development and brain disordersThe motile breast cancer phenotype roles of proteoglycans/glycosaminoglycans.Trp53 regulates Notch 4 signaling through Mdm2.Common integration sites for MMTV in viral induced mouse mammary tumors.eIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells.Expression of truncated eukaryotic initiation factor 3e (eIF3e) resulting from integration of mouse mammary tumor virus (MMTV) causes a shift from cap-dependent to cap-independent translation.INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cellsINT6 interacts with MIF4GD/SLIP1 and is necessary for efficient histone mRNA translation.The Drosophila orthologue of the INT6 onco-protein regulates mitotic microtubule growth and kinetochore structure.Translational control gone awry: a new mechanism of tumorigenesis and novel targets of cancer treatments.Decreased eIF3e/Int6 expression causes epithelial-to-mesenchymal transition in breast epithelial cells.Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium.eIF3m expression influences the regulation of tumorigenesis-related genes in human colon cancer.Int6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells.RNA interference-mediated silencing of eukaryotic translation initiation factor 3, subunit B (EIF3B) gene expression inhibits proliferation of colon cancer cells.The roles of stress-activated Sty1 and Gcn2 kinases and of the protooncoprotein homologue Int6/eIF3e in responses to endogenous oxidative stress during histidine starvation.An oncogenic role of eIF3e/INT6 in human breast cancer.
P2860
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P2860
Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Expression of truncated Int6/e ...... hyperplasia and tumorigenesis.
@ast
Expression of truncated Int6/e ...... hyperplasia and tumorigenesis.
@en
type
label
Expression of truncated Int6/e ...... hyperplasia and tumorigenesis.
@ast
Expression of truncated Int6/e ...... hyperplasia and tumorigenesis.
@en
prefLabel
Expression of truncated Int6/e ...... hyperplasia and tumorigenesis.
@ast
Expression of truncated Int6/e ...... hyperplasia and tumorigenesis.
@en
P2093
P2860
P356
P1476
Expression of truncated Int6/e ...... hyperplasia and tumorigenesis.
@en
P2093
Corinne A Boulanger
David L Mack
Gilbert H Smith
Robert Callahan
P2860
P2888
P356
10.1186/BCR1742
P577
2007-01-01T00:00:00Z
P5875
P6179
1042048727