Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death
about
Association of SAP130/SF3b-3 with Cullin-RING ubiquitin ligase complexes and its regulation by the COP9 signalosomeCOP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phaseThe subunit CSN6 of the COP9 signalosome is cleaved during apoptosisCSN complex controls the stability of selected synaptic proteins via a torsinA-dependent processGRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex IThe Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimerThe Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and RepairCrystal structure and versatile functional roles of the COP9 signalosome subunit 1ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer DevelopmentMultiple functions of Jab1 are required for early embryonic development and growth potential in miceAnalysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiationThe Evolution of COP9 Signalosome in Unicellular and Multicellular OrganismsFunction of COP9 signalosome in regulation of mouse oocytes meiosis by regulating MPF activity and securing degradationUrodele p53 tolerates amino acid changes found in p53 variants linked to human cancerDownregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stabilityUbiquitin, hormones and biotic stress in plantsGene expression in the placenta: maternal stress and epigenetic responses.COP9 subunits 4 and 5 target soluble guanylyl cyclase α1 and p53 in prostate cancer cells.Role of individual subunits of the Neurospora crassa CSN complex in regulation of deneddylation and stability of cullin proteins.Nedd8 on cullin: building an expressway to protein destruction.Bioinformatics study of cancer-related mutations within p53 phosphorylation site motifsRefined mapping of a quantitative trait locus on chromosome 1 responsible for mouse embryonic death.Analysis of candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 and -2.Recruitment of the inhibitor Cand1 to the cullin substrate adaptor site mediates interaction to the neddylation site.Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice.Substrate phosphorylation and feedback regulation in JFK-promoted p53 destabilization.Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.The eta7/csn3-3 auxin response mutant of Arabidopsis defines a novel function for the CSN3 subunit of the COP9 signalosome.Revisiting the COP9 signalosome as a transcriptional regulator.Neddylation and deneddylation in cardiac biologyThe COP9 signalosome and cullin-RING ligases in the heartThe COP9 signalosome and vascular function: intriguing possibilities?An eight-subunit COP9 signalosome with an intact JAMM motif is required for fungal fruit body formation.CSN6 deregulation impairs genome integrity in a COP1-dependent pathwayRole of Epithelial-Mesenchyme Transition in Chlamydia Pathogenesis.Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repairExpression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis.Knockdown of subunit 3 of the COP9 signalosome inhibits C2C12 myoblast differentiation via NF-KappaB signaling pathwayCOP9 signalosome subunit 6 (CSN6) regulates E6AP/UBE3A in cervical cancer.Differential Proteomic Analysis of Human Placenta-Derived Mesenchymal Stem Cells Cultured on Normal Tissue Culture Surface and Hyaluronan-Coated Surface.
P2860
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P2860
Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death
description
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2003
@ast
im Oktober 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/10/01)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/10/01)
@nl
наукова стаття, опублікована в жовтні 2003
@uk
مقالة علمية (نشرت في أكتوبر 2003)
@ar
name
Disruption of the COP9 signalo ...... n E, and early embryonic death
@ast
Disruption of the COP9 signalo ...... n E, and early embryonic death
@en
Disruption of the COP9 signalo ...... n E, and early embryonic death
@nl
type
label
Disruption of the COP9 signalo ...... n E, and early embryonic death
@ast
Disruption of the COP9 signalo ...... n E, and early embryonic death
@en
Disruption of the COP9 signalo ...... n E, and early embryonic death
@nl
prefLabel
Disruption of the COP9 signalo ...... n E, and early embryonic death
@ast
Disruption of the COP9 signalo ...... n E, and early embryonic death
@en
Disruption of the COP9 signalo ...... n E, and early embryonic death
@nl
P2093
P2860
P3181
P1476
Disruption of the COP9 signalo ...... n E, and early embryonic death
@en
P2093
Karin Lykke-Andersen
Laura Schaefer
Suchithra Menon
Xing-Wang Deng
P2860
P304
P3181
P356
10.1128/MCB.23.19.6790-6797.2003
P407
P577
2003-10-01T00:00:00Z