Stressing out the ER: a role of the unfolded protein response in prion-related disorders
about
Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosisCalcineurin inhibition at the clinical phase of prion disease reduces neurodegeneration, improves behavioral alterations and increases animal survivalER chaperones in mammalian development and human diseasesIn vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoformsA central role for calcineurin in protein misfolding neurodegenerative diseases.From structure to redox: The diverse functional roles of disulfides and implications in disease.Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration.Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegenerationEndoplasmic reticulum stress, PrP trafficking, and neurodegeneration.Perturbation of endoplasmic reticulum homeostasis facilitates prion replication.Prion protein misfolding affects calcium homeostasis and sensitizes cells to endoplasmic reticulum stress.Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathwayRedox control of prion and disease pathogenesis.ER stress-induced clearance of misfolded GPI-anchored proteins via the secretory pathway.Metabolism of minor isoforms of prion proteins: Cytosolic prion protein and transmembrane prion proteinStress protein expression in early phase spinal cord ischemia/reperfusion injuryAltered Prion protein expression pattern in CSF as a biomarker for Creutzfeldt-Jakob disease.The intricate mechanisms of neurodegeneration in prion diseases.Prion protein biosynthesis and its emerging role in neurodegeneration.Proteasomal dysfunction and endoplasmic reticulum stress enhance trafficking of prion protein aggregates through the secretory pathway and increase accumulation of pathologic prion proteinPDIA3 Knockdown Exacerbates Free Fatty Acid-Induced Hepatocyte Steatosis and Apoptosis.The impact of the unfolded protein response on human diseasePhenylbutyric acid suppresses protein accumulation-mediated ER stress in retrovirus-infected astrocytes and delays onset of paralysis in infected miceOverexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice.Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth.Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders.RAGE signaling contributes to neuroinflammation in infantile neuronal ceroid lipofuscinosisOpposing roles of prion protein in oxidative stress- and ER stress-induced apoptotic signaling.Emerging roles of extracellular vesicles in neurodegenerative disorders: focus on HIV-associated neurological complications.The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo.Coordination of autophagy and the proteasome in resolving endoplasmic reticulum stress.Role of calcineurin in neurodegeneration produced by misfolded proteins and endoplasmic reticulum stress.Therapeutic strategies against protein misfolding in neurodegenerative diseases.The essential biology of the endoplasmic reticulum stress response for structural and computational biologists.The chaperone Grp78 in protein folding disorders of the nervous system.A molecular web: endoplasmic reticulum stress, inflammation, and oxidative stress.Prion degradation pathways: Potential for therapeutic intervention.Abnormal calcium homeostasis and protein folding stress at the ER: A common factor in familial and infectious prion disorders.The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein.
P2860
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P2860
Stressing out the ER: a role of the unfolded protein response in prion-related disorders
description
2006 nî lūn-bûn
@nan
2006年の論文
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2006年学术文章
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2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
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2006年學術文章
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name
Stressing out the ER: a role of the unfolded protein response in prion-related disorders
@ast
Stressing out the ER: a role of the unfolded protein response in prion-related disorders
@en
type
label
Stressing out the ER: a role of the unfolded protein response in prion-related disorders
@ast
Stressing out the ER: a role of the unfolded protein response in prion-related disorders
@en
prefLabel
Stressing out the ER: a role of the unfolded protein response in prion-related disorders
@ast
Stressing out the ER: a role of the unfolded protein response in prion-related disorders
@en
P2860
P1476
Stressing out the ER: a role of the unfolded protein response in prion-related disorders
@en
P2093
Claudio A Hetz
Claudio Soto
P2860
P356
10.2174/156652406775574578
P577
2006-02-01T00:00:00Z