Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase. - Wikidata - awgldk - TriplyDB

Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase.

Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase.

http://www.wikidata.org/entity/Q36399510

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Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1 Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation Regulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombination MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity Regulation of Aicda expression and AID activity Etoposide induces nuclear re-localisation of AID First AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodies Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming Altered pattern of immunoglobulin hypermutation in mice deficient in Slip-GC protein miR-181b negatively regulates activation-induced cytidine deaminase in B cells ADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cells The interaction between AID and CIB1 is nonessential for antibody gene diversification by gene conversion or class switch recombination Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching Temporal regulation of Ig gene diversification revealed by single-cell imaging.Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization.APOBEC3B and AID have similar nuclear import mechanisms.Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Evolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase.Haploinsufficiency of activation-induced deaminase for antibody diversification and chromosome translocations both in vitro and in vivo.Two forms of activation-induced cytidine deaminase differing in their ability to bind agarose.AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations.Functions and regulation of the APOBEC family of proteins A coming-of-age story: activation-induced cytidine deaminase turns 10.Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA.Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitness Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.AID and somatic hypermutation.Activation-induced deaminase cloning, localization, and protein extraction from young VH-mutant rabbit appendix.Lysine residue at position 22 of the AID protein regulates its class switch activity.Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90.Activation-induced cytidine deaminase alters the subcellular localization of Tet family proteins.Targeting of somatic hypermutation.Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation Mechanism and regulation of class switch recombination Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein.Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination.

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P2860

Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase.

http://www.wikidata.org/entity/Q36399510

description

2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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2004年學術文章

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name

Somatic hypermutation is limit ...... activation-induced deaminase.

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Somatic hypermutation is limit ...... activation-induced deaminase.

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type

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Somatic hypermutation is limit ...... activation-induced deaminase.

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Somatic hypermutation is limit ...... activation-induced deaminase.

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prefLabel

Somatic hypermutation is limit ...... activation-induced deaminase.

@ast

Somatic hypermutation is limit ...... activation-induced deaminase.

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Journal of Experimental Medicine

P1476

Somatic hypermutation is limit ...... activation-induced deaminase.

@en

P2093

Almudena R Ramiro

http://www.w3.org/2001/XMLSchema#string

Kevin M McBride

http://www.w3.org/2001/XMLSchema#string

Pete Stavropoulos

http://www.w3.org/2001/XMLSchema#string

Vasco Barreto

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P2860

Nuclear envelope permeability

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway

The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay

AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization.

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

Nucleocytoplasmic transport: the soluble phase

Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

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1235-1244

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scholarly article

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10.1084/JEM.20040373

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9

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199

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Michel C. Nussenzweig

Pete Stavropoulos

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2004-04-26T00:00:00Z

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8587263

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15117971

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2211910

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