about
The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substratesRegulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombinationImmunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophilsEpigenetics of Peripheral B-Cell Differentiation and the Antibody ResponseMicroRNAs in B cell development and malignancyTranscriptional stalling in B-lymphocytes: a mechanism for antibody diversification and maintenance of genomic integrityRelated Mechanisms of Antibody Somatic Hypermutation and Class Switch RecombinationTransposon-mediated adaptive and directed mutations and their potential evolutionary benefitsIntestinal IgA production and its role in host-microbe interactionAID targeting: old mysteries and new challengesPractical guidelines for B-cell receptor repertoire sequencing analysisIntegrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in miceEvolution of phosphorylation-dependent regulation of activation-induced cytidine deaminase.Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae.Haploinsufficiency of activation-induced deaminase for antibody diversification and chromosome translocations both in vitro and in vivo.Ab-origin: an enhanced tool to identify the sourcing gene segments in germline for rearranged antibodiesA cis-acting diversification activator both necessary and sufficient for AID-mediated hypermutation.Functions and regulation of the APOBEC family of proteinsA coming-of-age story: activation-induced cytidine deaminase turns 10.Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation.Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma.Generation and repair of AID-initiated DNA lesions in B lymphocytes.GANP interacts with APOBEC3G and facilitates its encapsidation into the virions to reduce HIV-1 infectivityClassical Mus musculus Igκ enhancers support transcription but not high level somatic hypermutation from a V-lambda promoter in chicken DT40 cells.Prognostic B-cell signatures using mRNA-seq in patients with subtype-specific breast and ovarian cancer.AID and somatic hypermutation.A single-strand specific lesion drives MMS-induced hyper-mutability at a double-strand break in yeast.Specific recruitment of protein kinase A to the immunoglobulin locus regulates class-switch recombination.Mimicking the germinal center reaction in hybridoma cells to isolate temperature-selective anti-PEG antibodies.Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutationLocal sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification.DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.Innate signaling networks in mucosal IgA class switchingViral double-stranded RNA triggers Ig class switching by activating upper respiratory mucosa B cells through an innate TLR3 pathway involving BAFF.The regulation of IgA class switching.Targeting of AID-mediated sequence diversification to immunoglobulin genesDamage-induced localized hypermutability.Clinical observations on chemotherapy curable malignancies: unique genetic events, frozen development and enduring apoptotic potential.Genetic diversity of the allodeterminant alr2 in Hydractinia symbiolongicarpusDetecting selection in immunoglobulin sequences
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Targeting of somatic hypermutation.
@ast
Targeting of somatic hypermutation.
@en
Targeting of somatic hypermutation.
@nl
type
label
Targeting of somatic hypermutation.
@ast
Targeting of somatic hypermutation.
@en
Targeting of somatic hypermutation.
@nl
prefLabel
Targeting of somatic hypermutation.
@ast
Targeting of somatic hypermutation.
@en
Targeting of somatic hypermutation.
@nl
P2860
P356
P1476
Targeting of somatic hypermutation.
@en
P2093
David G Schatz
Valerie H Odegard
P2860
P304
P356
10.1038/NRI1896
P577
2006-08-01T00:00:00Z