Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice.
about
Immunosenescence: emerging challenges for an ageing populationAge-Associated B Cells: A T-bet-Dependent Effector with Roles in Protective and Pathogenic ImmunityChanges in primary lymphoid organs with agingImmunosenescence and organ transplantationImmunosenescence: deficits in adaptive immunity in the elderlyAging and immune function: molecular mechanisms to interventionsAging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitorsInterleukin-7 and Immunosenescence.Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge.T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosisTranscriptional profiling of mRNAs and microRNAs in human bone marrow precursor B cells identifies subset- and age-specific variations.A B-cell subset uniquely responsive to innate stimuli accumulates in aged miceAging impairs murine B cell differentiation and function in primary and secondary lymphoid tissuesInhibition of B Lymphopoiesis by Adipocytes and IL-1-Producing Myeloid-Derived Suppressor CellsEffects of aging on early B- and T-cell development.B cells, E2A, and aging.B cells and aging: gauging the interplay of generative, selective, and homeostatic events.Targets of immune regeneration in rheumatoid arthritis.B cells in the aging immune system: time to consider B-1 cells.Causes, consequences, and reversal of immune system aging.Bone marrow fat and the decline of B lymphopoiesis in rabbitsAging, B lymphopoiesis, and patterns of leukemogenesis.B cells and aging: balancing the homeostatic equationIn senescence, age-associated B cells secrete TNFα and inhibit survival of B-cell precursorsMEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis.Theory and strategy for Pneumococcal vaccines in the elderly.Old mice retain bone marrow B1 progenitors, but lose B2 precursors, and exhibit altered immature B cell phenotype and light chain usage.NK cells in the CD19- B220+ bone marrow fraction are increased in senescence and reduce E2A and surrogate light chain proteins in B cell precursors.Deviation of the B cell pathway in senescent mice is associated with reduced surrogate light chain expression and altered immature B cell generation, phenotype, and light chain expressionB cells and aging: molecules and mechanisms.Impaired B lymphopoiesis in old age: a role for inflammatory B cells?Impact of immunosenescence on transplant outcome.A comparative review of aging and B cell function in mice and humansIBD across the age spectrum: is it the same disease?Hematopoietic stem cell aging and chronic lymphocytic leukemia pathogenesis.Immune senescence: significance of the stromal microenvironment.The Intersection Of Aging Biology and The Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop.Effects of age-related shifts in cellular function and local microenvironment upon the innate immune response to implants.Macrophages in age-related chronic inflammatory diseases.In old BALB/c mice, bone marrow pre-B cell and surrogate light chain reduction is associated with increased B cell reactivity to phosphorylcholine, but reduced T15 idiotype dominance.
P2860
Q24655433-BAE4D243-5F2D-4BDD-8F57-F1927FCF81D9Q26795654-34F72D85-98E1-4ECD-A0A3-1044C882D3F5Q26825505-19491252-D509-41C0-B02A-2401ACA50710Q26861735-8ED6F347-FC9B-45EA-9C08-BD6EEFB42043Q28238448-A52FAED5-0063-402F-B67E-3C08F9E50C6CQ28387056-1E599799-3316-4F18-8DE5-00E9900BC9BEQ28395194-401C9969-CAF5-4D0D-BE7A-E2FD89DE2BE8Q33582101-3D80B660-0CBE-4658-A92C-20B8A4BCE8C2Q33696554-6D3193CD-A101-4FBF-97F9-11EEB7678BB4Q33954374-E35B1952-8F71-4820-A3A7-FCE433E89957Q34923498-1C1DD517-6887-4F71-B6EF-0B740E56714EQ35153782-4C9D539A-18BF-46AF-94B2-C61616D3F87CQ35806803-DEB11909-2F89-4DC7-A0B4-E31182C4EBA2Q36031591-03A1FB99-E879-4E73-8B7F-41BEC13B748FQ36120995-FC5F7A10-513E-48B5-B312-93FE3A308550Q36121005-D54D12C8-660A-4E22-BF93-98985276EDDDQ36121011-B378CE13-8DED-451F-A5F7-E230B53F7F8DQ36160188-0BB00CCD-52D0-4A85-B686-7AC48BFCC284Q36372758-804DCF79-9576-4BF3-B32F-B000CBDA2618Q36638131-D6EF5134-E9EB-46F8-ABDA-33FDBA2C2798Q36642445-F18B1F71-C95E-43A1-8ED4-DFA62EF08F92Q36690520-2AEB4277-344D-448B-9645-F0A6785077B6Q36753903-F700B242-E9E5-4EF0-A5C2-8E61A7558DC1Q37026934-B8F37BA6-160E-4FED-87BE-279D1FFE0795Q37181211-A4CE2F5F-E329-4872-8434-CDBB192F85C3Q37309215-A044C5A4-1881-4680-85FD-F36B1F23C0D3Q37324955-532E6236-FD9C-4F7C-BFEC-AD9654551607Q37345121-9930B0D5-684F-415D-B4E4-57DCF1B4A63DQ37359108-A12570CE-B465-41DF-B06A-5456355EF28CQ37398750-C362E728-0A9C-48FE-BD30-85416E41BF70Q37679476-36819502-C4A4-4A0D-BE7F-097C8A9F477EQ38063349-884B21B5-3639-4B38-9EE2-9AC1AF42F17CQ38128010-4A9899BE-A206-4097-889F-B6F6921DECA5Q38171927-93BB031C-D4CF-4F67-A976-5AF6DAE53ED3Q38237615-F532E436-B610-4E43-9CA6-954CA917C50BQ38928710-63AE3934-453C-46A5-8C2A-9EF7DD1B34A3Q39302712-FE5AF8AD-ECCA-4EA0-BF26-0D7E2D16D3A8Q39327060-E59B8C4B-3611-4A89-8C62-EBE94A27565BQ39443058-A9B2EB22-B55D-4E30-BB16-3090B1E45A2EQ40439971-8356547B-465B-49E5-9899-56F30810BBEF
P2860
Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Bone marrow microenvironmental ...... cell generation in aged mice.
@ast
Bone marrow microenvironmental ...... cell generation in aged mice.
@en
type
label
Bone marrow microenvironmental ...... cell generation in aged mice.
@ast
Bone marrow microenvironmental ...... cell generation in aged mice.
@en
prefLabel
Bone marrow microenvironmental ...... cell generation in aged mice.
@ast
Bone marrow microenvironmental ...... cell generation in aged mice.
@en
P2093
P2860
P356
P1476
Bone marrow microenvironmental ...... cell generation in aged mice.
@en
P2093
Alex P Sah
David M Allman
Joseph E Labrie
Michael P Cancro
Rachel M Gerstein
P2860
P304
P356
10.1084/JEM.20040845
P407
P577
2004-08-01T00:00:00Z