Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice
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The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombinationThe plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombinationRecombination-activating gene proteins: more regulation, pleaseA PHD finger motif in the C terminus of RAG2 modulates recombination activityElucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid bindingRAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of 'alternative NHEJ'.Analysis of mutations from SCID and Omenn syndrome patients reveals the central role of the Rag2 PHD domain in regulating V(D)J recombination.An autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation.Mobilization of RAG-generated signal ends by transposition and insertion in vivoAutoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombinationCoupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis.The C-terminal portion of RAG2 protects against transposition in vitroOverlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells.Leaky RAG Deficiency in Adult Patients with Impaired Antibody Production against Bacterial Polysaccharide AntigensThe bounty of RAGs: recombination signal complexes and reaction outcomes.Artemis sheds new light on V(D)J recombination.How to keep V(D)J recombination under control.Monoallelic gene expression: a repertoire of recurrent themes.New concepts in the regulation of an ancient reaction: transposition by RAG1/RAG2.Activation of 12/23-RSS-dependent RAG cleavage by hSWI/SNF complex in the absence of transcription.A dual interaction between the DNA damage response protein MDC1 and the RAG1 subunit of the V(D)J recombinaseImpaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice.RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repairUnderstanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition.Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination.RAG2's non-core domain contributes to the ordered regulation of V(D)J recombination.Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctionsA plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement.RAG: a recombinase diversified.Temporal and spatial regulation of V(D)J recombination: interactions of extrinsic factors with the RAG complex.Noncore RAG1 regions promote Vβ rearrangements and αβ T cell development by overcoming inherent inefficiency of Vβ recombination signal sequences.Allelic exclusion of immunoglobulin genes: models and mechanisms.Full-length RAG-2, and not full-length RAG-1, specifically suppresses RAG-mediated transposition but not hybrid joint formation or disintegration.Congenital defects in V(D)J recombination.V(D)J Recombination: Mechanism, Errors, and Fidelity.Modeling of the RAG reaction mechanism.The ATM Kinase Restrains Joining of Both VDJ Signal and Coding Ends.Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice.
P2860
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P2860
Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice
@ast
Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice
@en
Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice
@nl
type
label
Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice
@ast
Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice
@en
Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice
@nl
prefLabel
Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice
@ast
Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice
@en
Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice
@nl
P2093
P2860
P356
P1476
Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice
@en
P2093
Craig H Bassing
Darryll D Dudley
Frank Gartner
Frederick W Alt
Marjorie A Oettinger
Robert Monroe
Sadiqur R Talukder
Sheryl K Elkin
Yoshiko Akamatsu
Yousuke Takahama
P2860
P304
P356
10.1073/PNAS.0237043100
P407
P577
2003-01-16T00:00:00Z