Transporters as a determinant of drug clearance and tissue distribution.
about
How drugs get into cells: tested and testable predictions to help discriminate between transporter-mediated uptake and lipoidal bilayer diffusionOrganic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin GThe role of transporters in toxicity and diseasePhysiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation.Structure and function of ABCG2-rich extracellular vesicles mediating multidrug resistanceImproving cell-based therapies by nanomodificationInhibition of OATP-1B1 and OATP-1B3 by tyrosine kinase inhibitorsFitting the elementary rate constants of the P-gp transporter network in the hMDR1-MDCK confluent cell monolayer using a particle swarm algorithmMembrane transporters in drug developmentOlfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anionsPrediction of hepatic clearance in human from in vitro data for successful drug development.Urinary coproporphyrin I/(I + III) ratio as a surrogate for MRP2 or other transporter activities involved in methotrexate clearance.Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1.Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1Intracellular drug concentrations.Mechanisms and assessment of statin-related muscular adverse effects.Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it.Modulation of the cellular accumulation and intracellular activity of daptomycin towards phagocytized Staphylococcus aureus by the P-glycoprotein (MDR1) efflux transporter in human THP-1 macrophages and madin-darby canine kidney cells.Differential expression of several drug transporter genes in HepG2 and Huh-7 cell lines.Pain management for dentists: the role of ibuprofen.Influence of SLCO1B1 and CYP2C8 gene polymorphisms on rosiglitazone pharmacokinetics in healthy volunteersUsing the BacMam Baculovirus System to Study Expression and Function of Recombinant Efflux Drug Transporters in Polarized Epithelial Cell MonolayersAssessment of potential drug interactions by characterization of human drug metabolism pathways using non-invasive bile sampling.Functional characterization of ABCB4 mutations found in progressive familial intrahepatic cholestasis type 3In vitro-in vivo extrapolation of hepatic clearance: biological tools, scaling factors, model assumptions and correct concentrations.Transporter-mediated uptake into cellular compartments.A perspective on efflux transport proteins in the liverPredicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption.Nanovehicular intracellular delivery systems.Role of OATP transporters in the disposition of drugs.Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Polymorphism in human organic cation transporters and metformin action.Interindividual variability of methadone response: impact of genetic polymorphism.Inhibition of flucloxacillin tubular renal secretion by piperacillinUse of sandwich-cultured human hepatocytes to predict biliary clearance of angiotensin II receptor blockers and HMG-CoA reductase inhibitors.Effects of drug transporters on volume of distribution.Simulations of the nonlinear dose dependence for substrates of influx and efflux transporters in the human intestineInterindividual variability in hepatic organic anion-transporting polypeptides and P-glycoprotein (ABCB1) protein expression: quantification by liquid chromatography tandem mass spectroscopy and influence of genotype, age, and sexGenetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs.Organic cation transporters and their roles in antiretroviral drug disposition.
P2860
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P2860
Transporters as a determinant of drug clearance and tissue distribution.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Transporters as a determinant of drug clearance and tissue distribution.
@ast
Transporters as a determinant of drug clearance and tissue distribution.
@en
type
label
Transporters as a determinant of drug clearance and tissue distribution.
@ast
Transporters as a determinant of drug clearance and tissue distribution.
@en
prefLabel
Transporters as a determinant of drug clearance and tissue distribution.
@ast
Transporters as a determinant of drug clearance and tissue distribution.
@en
P2093
P1476
Transporters as a determinant of drug clearance and tissue distribution.
@en
P2093
Toshiharu Horie
Yoshihisa Shitara
Yuichi Sugiyama
P304
P356
10.1016/J.EJPS.2005.12.003
P407
P577
2006-02-20T00:00:00Z