Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis. - Wikidata - awgldk - TriplyDB

Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis.

Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis.

http://www.wikidata.org/entity/Q36403300

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Human T regulatory cell therapy: take a billion or so and call me in the morning CD28 co-stimulation in T-cell homeostasis: a recent perspective Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies Temporal pattern of ICAM-I mediated regulatory T cell recruitment to sites of inflammation in adoptive transfer model of multiple sclerosis.A CD28 superagonistic antibody elicits 2 functionally distinct waves of T cell activation in rats.Activation of regulatory T cells during inflammatory response is not an exclusive property of stem cells Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells The calm after the cytokine storm: lessons from the TGN1412 trial.Models of autoimmune demyelination in the central nervous system: on the way to translational medicine.Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice.Enhancement of antigen-specific Treg vaccination in vivo.Inflammatory and autoimmune reactions in atherosclerosis and vaccine design informatics.Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis.Costimulatory pathways in transplantation.After TGN1412: recent developments in cytokine release assays.Regulatory T cells modulate inflammation and reduce infarct volume in experimental brain ischaemia Sequential induction of effector function, tissue migration and cell death during polyclonal activation of mouse regulatory T-cells.Compared benefit of approved and experimental immunosuppressive therapeutic approaches in multiple sclerosis.A superagonistic monoclonal antibody for CD28 ameliorates crescentic glomerulonephritis in wistar-kyoto rats Supplementation of CD4+CD25+ regulatory T cells suppresses experimental autoimmune uveoretinitis.Transient regulatory T-cells: a state attained by all activated human T-cells.Foxp3+ regulatory T cells control persistence of viral CNS infection Granzyme B- and Fas ligand-mediated cytotoxic function induced by mitogenic CD28 stimulation of human memory CD4+ T cells TGN1412 Induces Lymphopenia and Human Cytokine Release in a Humanized Mouse Model Targeting Treg signaling for the treatment of autoimmune diseases Imbalance of regulatory T cells in human autoimmune diseases.Immune reconstitution and graft-versus-host reactions in rat models of allogeneic hematopoietic cell transplantation Inhibition of midkine alleviates experimental autoimmune encephalomyelitis through the expansion of regulatory T cell population.Novel therapies for rheumatoid arthritis.Humanized mice, a new model to study the influence of drug treatment on neonatal sepsis Controlled release formulations of IL-2, TGF-β1 and rapamycin for the induction of regulatory T cells.Severity of the TGN1412 trial disaster cytokine storm correlated with IL-2 release.Regulatory T cells and human disease Neuromodulatory activities of CD4+CD25+ regulatory T cells in a murine model of HIV-1-associated neurodegeneration.Enhancing the ability of experimental autoimmune encephalomyelitis to serve as a more rigorous model of multiple sclerosis through refinement of the experimental design CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes Virus infection drives IL-2 antibody complexes into pro-inflammatory agonists in mice.Regulatory T cells ameliorate intrauterine growth retardation in a transgenic rat model for preeclampsia Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells.The Role of Immunogenicity in Cardiovascular Disease.

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P2860

Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis.

http://www.wikidata.org/entity/Q36403300

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Selective targeting of regulat ...... autoimmune encephalomyelitis.

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Selective targeting of regulat ...... autoimmune encephalomyelitis.

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Chia-Huey Lin

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Jens Schmidt

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Karen Balbach

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Klaus V Toyka

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Niklas Beyersdorf

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Ralf Gold

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Stefanie Gaupp

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Thomas Hanke

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Thomas Hünig

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Thomas Kerkau

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P2860

Topological requirements and signaling properties of T cell-activating, anti-CD28 antibody superagonists

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

Control of regulatory T cell development by the transcription factor Foxp3

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

Alternative activation of macrophages

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

Crystal structure of a soluble CD28-Fab complex

Multiple immuno-regulatory defects in type-1 diabetes

Regulatory T cell lineage specification by the forkhead transcription factor foxp3

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experimental autoimmune encephalomyelitis

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