Comprehensive Analysis of Structure-Activity Relationships of α-Ketoheterocycles as sn-1-Diacylglycerol Lipase α Inhibitors

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A novel live cell assay to measure diacylglycerol lipase α activity The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface.

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P2860

Comprehensive Analysis of Structure-Activity Relationships of α-Ketoheterocycles as sn-1-Diacylglycerol Lipase α Inhibitors

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Comprehensive Analysis of Stru ...... ylglycerol Lipase α Inhibitors

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Comprehensive Analysis of Stru ...... ylglycerol Lipase α Inhibitors

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Comprehensive Analysis of Stru ...... ylglycerol Lipase α Inhibitors

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Comprehensive Analysis of Stru ...... ylglycerol Lipase α Inhibitors

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Comprehensive Analysis of Stru ...... ylglycerol Lipase α Inhibitors

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Comprehensive Analysis of Stru ...... ylglycerol Lipase α Inhibitors

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Comprehensive Analysis of Stru ...... ylglycerol Lipase α Inhibitors

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Dale L Boger

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Jessica J A Hummel

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Mario van der Stelt

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P2860

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Parsing the players: 2-arachidonoylglycerol synthesis and degradation in the CNS

Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone

Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants

Reversible Competitive α-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Constraints in the Acyl Side Chain: Orally Active, Long-Acting Analgesics

Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice

The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission

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Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation.

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scholarly article

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10.1021/ACS.JMEDCHEM.5B01627

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English

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Comprehensive Analysis of Structure-Activity Relationships of α-Ketoheterocycles as sn-1-Diacylglycerol Lipase α Inhibitors

about

P2860

P2860

Comprehensive Analysis of Structure-Activity Relationships of α-Ketoheterocycles as sn-1-Diacylglycerol Lipase α Inhibitors

description

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type

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P1433

P1476

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P478

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P932