PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility
about
The emerging importance of group II PAKsThe tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathwaysPyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survivalFocal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motilityPhosphorylation-mediated regulation of GEFs for RhoAFrom mechanical force to RhoA activationThe on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migrationNuclear FAK: a new mode of gene regulation from cellular adhesionsFAK in cancer: mechanistic findings and clinical applicationsRgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell motility downstream of integrinsDifferential regulation of adhesion complex turnover by ROCK1 and ROCK2Cortactin as a target for FAK in the regulation of focal adhesion dynamicsAn adhesion-dependent switch between mechanisms that determine motile cell shapePAK4: a pluripotent kinase that regulates prostate cancer cell adhesion.Proline-rich tyrosine kinase 2 regulates hippocampal long-term depressionSpatial regulation of RhoC activity defines protrusion formation in migrating cellsCell adhesion: integrating cytoskeletal dynamics and cellular tension.The mTOR-FAK mechanotransduction signaling axis for focal adhesion maturation and cell proliferation.FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendodermFAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells.Focal adhesion kinase promotes integrin adhesion dynamics necessary for chemotropic turning of nerve growth cones.Compensatory endocytosis in bladder umbrella cells occurs through an integrin-regulated and RhoA- and dynamin-dependent pathway.SRChing for the substrates of Src.Focal adhesion kinase and endothelial cell apoptosis.Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge.Force-induced cell polarisation is linked to RhoA-driven microtubule-independent focal-adhesion slidingRegulation of adhesion dynamics by calpain-mediated proteolysis of focal adhesion kinase (FAK).Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activationThe Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins.PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.Focal adhesion kinase can play unique and opposing roles in regulating the morphology of differentiating oligodendrocytesTargeting Pyk2 for therapeutic interventionFAK is required for Schwann cell spreading on immature basal lamina to coordinate the radial sorting of peripheral axons with myelinationKeratin 8/18 regulation of cell stiffness-extracellular matrix interplay through modulation of Rho-mediated actin cytoskeleton dynamics.Estrogen-related receptor α decreases RHOA stability to induce orientated cell migration.p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase.Movers and shakers: cell cytoskeleton in cancer metastasis.Integrin-specific control of focal adhesion kinase and RhoA regulates membrane protrusion and invasion.Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity.
P2860
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P2860
PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
PyK2 and FAK connections to p1 ...... n formation, and cell motility
@ast
PyK2 and FAK connections to p1 ...... n formation, and cell motility
@en
type
label
PyK2 and FAK connections to p1 ...... n formation, and cell motility
@ast
PyK2 and FAK connections to p1 ...... n formation, and cell motility
@en
prefLabel
PyK2 and FAK connections to p1 ...... n formation, and cell motility
@ast
PyK2 and FAK connections to p1 ...... n formation, and cell motility
@en
P2093
P2860
P50
P356
P1476
PyK2 and FAK connections to p1 ...... n formation, and cell motility
@en
P2093
Alok Tomar
David D Schlaepfer
Gary Bokoch
Jinbin Zhai
Joie A Bernard-Trifilo
Perihan Nalbant
Rafaela Canete-Soler
Sean A Uryu
Ssang-Taek Lim
P2860
P304
P356
10.1083/JCB.200708194
P407
P577
2008-01-01T00:00:00Z