Altered APP processing in insulin-resistant conditions is mediated by autophagosome accumulation via the inhibition of mammalian target of rapamycin pathway.
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Metabolic Risk Factors of Sporadic Alzheimer's Disease: Implications in the Pathology, Pathogenesis and TreatmentThe impairment of insulin signaling in Alzheimer's diseaseAberrant insulin signaling in Alzheimer's disease: current knowledgeReduced IRE1α mediates apoptotic cell death by disrupting calcium homeostasis via the InsP3 receptor.Chronic adiponectin deficiency leads to Alzheimer's disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice.Palmitic Acid-BSA enhances Amyloid-β production through GPR40-mediated dual pathways in neuronal cells: Involvement of the Akt/mTOR/HIF-1α and Akt/NF-κB pathwaysHyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer's disease.CR6-interacting factor 1 is a key regulator in Aβ-induced mitochondrial disruption and pathogenesis of Alzheimer's disease.Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway.Insulin-degrading enzyme secretion from astrocytes is mediated by an autophagy-based unconventional secretory pathway in Alzheimer disease.Autophagy impairment mediated by S-nitrosation of ATG4B leads to neurotoxicity in response to hyperglycemia.Activation of mTOR: a culprit of Alzheimer's disease?Can insulin signaling pathways be targeted to transport Aβ out of the brain?Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons.Exosomes in the Pathology of Neurodegenerative Diseases.The β-amyloid precursor protein analog P165 improves impaired insulin signal transduction in type 2 diabetic rats.Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer's disease models.
P2860
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P2860
Altered APP processing in insulin-resistant conditions is mediated by autophagosome accumulation via the inhibition of mammalian target of rapamycin pathway.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
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name
Altered APP processing in insu ...... n target of rapamycin pathway.
@ast
Altered APP processing in insu ...... n target of rapamycin pathway.
@en
type
label
Altered APP processing in insu ...... n target of rapamycin pathway.
@ast
Altered APP processing in insu ...... n target of rapamycin pathway.
@en
prefLabel
Altered APP processing in insu ...... n target of rapamycin pathway.
@ast
Altered APP processing in insu ...... n target of rapamycin pathway.
@en
P2093
P2860
P356
P1433
P1476
Altered APP processing in insu ...... n target of rapamycin pathway.
@en
P2093
Hak Chul Jang
Hyundong Song
Inhee Mook-Jung
Jayoung Byun
Kyong Soo Park
Sung Min Son
Young Joo Park
P2860
P304
P356
10.2337/DB11-1735
P407
P577
2012-07-24T00:00:00Z