An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.
about
Human exonuclease I is required for 5' and 3' mismatch repairThe base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrityDNA polymerase delta is required for human mismatch repair in vitroThe mismatch repair system is required for S-phase checkpoint activationATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adductsThe histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSαMethylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2Mechanisms of resistance to alkylating agentsTumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancerThe MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repairMSH2 missense mutations alter cisplatin cytotoxicity and promote cisplatin-induced genome instabilityPCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cellsReplication past O(6)-methylguanine by yeast and human DNA polymerase eta.DNA replication fidelity and cancerInter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair researchSeparation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genesPartial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein ADHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSalpha/hMutSbeta ratio and reduces the efficiency of base-base mismatch repairIsolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalphaRole of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.Proteolysis of the mismatch repair protein MLH1 by caspase-3 promotes DNA damage-induced apoptosis.A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway.Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells.Reconstitution of Saccharomyces cerevisiae DNA polymerase ε-dependent mismatch repair with purified proteins.The role of mismatch repair in the prevention of base pair mutations in Saccharomyces cerevisiae.Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis.A sensitive scanning technology for low frequency nuclear point mutations in human genomic DNA.Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage.Interactions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway.Mismatch repair deficiency does not mediate clinical resistance to temozolomide in malignant gliomaInteraction between human mismatch repair recognition proteins and checkpoint sensor Rad9-Rad1-Hus1Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment.Deficiency of a novel mismatch repair activity in a bladder tumor cell line.High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6.Functional significance of concomitant inactivation of hMLH1 and hMSH6 in tumor cells of the microsatellite mutator phenotype.Mismatch repair processing of carcinogen-DNA adducts triggers apoptosisMismatch repair mutants in yeast are not defective in transcription-coupled DNA repair of UV-induced DNA damage.Mismatch repair in correction of replication errors and processing of DNA damage.O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation.Influence of cell cycle checkpoints and p53 function on the toxicity of temozolomide in human pancreatic cancer cells.
P2860
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P2860
An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
An alkylation-tolerant, mutato ...... rand-specific mismatch repair.
@ast
An alkylation-tolerant, mutato ...... rand-specific mismatch repair.
@en
type
label
An alkylation-tolerant, mutato ...... rand-specific mismatch repair.
@ast
An alkylation-tolerant, mutato ...... rand-specific mismatch repair.
@en
prefLabel
An alkylation-tolerant, mutato ...... rand-specific mismatch repair.
@ast
An alkylation-tolerant, mutato ...... rand-specific mismatch repair.
@en
P2093
P2860
P356
P1476
An alkylation-tolerant, mutato ...... trand-specific mismatch repair
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.14.6424
P407
P577
1993-07-01T00:00:00Z