Self-destruction and tolerance in resistance of mammalian cells to alkylation damage.
about
Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agentsMismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase.Extending the chemistry that supports genetic information transfer in vivo: phosphorothioate DNA, phosphorothioate RNA, 2'-O-methyl RNA, and methylphosphonate DNAInteractions of human mismatch repair proteins MutSalpha and MutLalpha with proteins of the ATR-Chk1 pathway.DNA-substrate sequence specificity of human G:T mismatch repair activity.Cloning and expression of the Xenopus and mouse Msh2 DNA mismatch repair genes.Mismatch repair proficiency and in vitro response to 5-fluorouracil.Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent.Biochemical analysis of the human mismatch repair proteins hMutSα MSH2(G674A)-MSH6 and MSH2-MSH6(T1219D)O6-methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma.Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiationDirect measurement of cyclic current-voltage responses of integral membrane proteins at a self-assembled lipid-bilayer-modified electrode: cytochrome f and cytochrome c oxidaseAn alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.hMutSalpha- and hMutLalpha-dependent phosphorylation of p53 in response to DNA methylator damage.Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteinsDecoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells.Homeostatic responses of colonic LGR5+ stem cells following acute in vivo exposure to a genotoxic carcinogenMechanisms of chemoresistance to alkylating agents in malignant glioma.Rad9 plays an important role in DNA mismatch repair through physical interaction with MLH1The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agentsTreatment resistance mechanisms of malignant glioma tumor stem cellsCompetency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine.Proteomic analysis of mismatch repair-mediated alkylating agent-induced DNA damage response.In vitro and in vivo modulations of benzo[c]phenanthrene-DNA adducts by DNA mismatch repair system.Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.MGMT testing--the challenges for biomarker-based glioma treatment.Radiobiological evaluation and correlation with the local effect model (LEM) of carbon ion radiation therapy and temozolomide in glioblastoma cell lines.Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro.MLH1- and ATM-dependent MAPK signaling is activated through c-Abl in response to the alkylator N-methyl-N'-nitro-N'-nitrosoguanidine.Inactive O6-methylguanine-DNA methyltransferase in human cells.Methylation tolerance in mismatch repair proficient cells with low MSH2 protein level.Combined mismatch and nucleotide excision repair defects in a human cell line: mismatch repair processes methylation but not UV- or ionizing radiation-induced DNA damage.Cisplatin and adriamycin resistance are associated with MutLalpha and mismatch repair deficiency in an ovarian tumor cell line.Strand-specific mismatch repair in mammalian cells.Recognition of DNA alterations by the mismatch repair systemMismatch repair-dependent iterative excision at irreparable O6-methylguanine lesions in human nuclear extracts.Repair of O6-alkylguanines in the nuclear DNA of human lymphocytes and leukaemic cells: analysis at the single-cell levelMouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O(6)-methylguanine due to high E2F1 regulated mismatch repair.The 3' --> 5' exonuclease of T4 DNA polymerase removes premutagenic alkyl mispairs and contributes to futile cycling at O6-methylguanine lesions.
P2860
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P2860
Self-destruction and tolerance in resistance of mammalian cells to alkylation damage.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
1992年學術文章
@zh
1992年學術文章
@zh-hant
name
Self-destruction and tolerance in resistance of mammalian cells to alkylation damage.
@ast
Self-destruction and tolerance in resistance of mammalian cells to alkylation damage.
@en
type
label
Self-destruction and tolerance in resistance of mammalian cells to alkylation damage.
@ast
Self-destruction and tolerance in resistance of mammalian cells to alkylation damage.
@en
prefLabel
Self-destruction and tolerance in resistance of mammalian cells to alkylation damage.
@ast
Self-destruction and tolerance in resistance of mammalian cells to alkylation damage.
@en
P2860
P356
P1476
Self-destruction and tolerance in resistance of mammalian cells to alkylation damage.
@en
P2093
P2860
P304
P356
10.1093/NAR/20.12.2933
P407
P577
1992-06-01T00:00:00Z