Secondary structure and gating rearrangements of transmembrane segments in rat P2X4 receptor channels.
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Polar residues in the second transmembrane domain of the rat P2X2 receptor that affect spontaneous gating, unitary conductance, and rectificationInsights into the channel gating of P2X receptors from structures, dynamics and small moleculesPore architecture and ion sites in acid-sensing ion channels and P2X receptorsFusion-activated Ca2+ entry via vesicular P2X4 receptors promotes fusion pore opening and exocytotic content release in pneumocytesP2X4 receptors in activated C8-B4 cells of cerebellar microglial origin.P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH.Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse.Pore-opening mechanism in trimeric P2X receptor channelsIdentification of functionally important residues of the rat P2X4 receptor by alanine scanning mutagenesis of the dorsal fin and left flipper domains.Structural insights into the function of P2X4: an ATP-gated cation channel of neuroendocrine cells.Multiple roles of the extracellular vestibule amino acid residues in the function of the rat P2X4 receptor.The second transmembrane domain of P2X7 contributes to dilated pore formationActivation and regulation of purinergic P2X receptor channelsCalcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion.Loop diuretic and ion-binding residues revealed by scanning mutagenesis of transmembrane helix 3 (TM3) of Na-K-Cl cotransporter (NKCC1)Fourier transform coupled to tryptophan-scanning mutagenesis: lessons from its application to the prediction of secondary structure in the acetylcholine receptor lipid-exposed transmembrane domains.Cysteine substitution mutagenesis and the effects of methanethiosulfonate reagents at P2X2 and P2X4 receptors support a core common mode of ATP action at P2X receptors.Tryptophan scanning of the acetylcholine receptor's betaM4 transmembrane domain: decoding allosteric linkage at the lipid-protein interface with ion-channel gating.Allosteric modulation of ATP-gated P2X receptor channelsVoltage- and [ATP]-dependent gating of the P2X(2) ATP receptor channel.Gating the pore of P2X receptor channelsInter- and intrasubunit interactions between transmembrane helices in the open state of P2X receptor channels.Key sites for P2X receptor function and multimerization: overview of mutagenesis studies on a structural basis.Permeation properties of a P2X receptor in the green algae Ostreococcus tauri.P2X Receptor Activation.Fourier transform coupled tryptophan scanning mutagenesis identifies a bending point on the lipid-exposed δM3 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor.Highly conserved tyrosine 37 stabilizes desensitized states and restricts calcium permeability of ATP-gated P2X3 receptor.Functional relevance of aromatic residues in the first transmembrane domain of P2X receptors.Functional interactions between P2X4 and P2X7 receptors from mouse salivary epithelia.On the role of the first transmembrane domain in cation permeability and flux of the ATP-gated P2X2 receptor.Participation of the Lys313-Ile333 sequence of the purinergic P2X4 receptor in agonist binding and transduction of signals to the channel gate.Functional characterization of mutants in the transmembrane domains of the rat P2X7 receptor that regulate pore conductivity and agonist sensitivity.Tryptophan scanning mutagenesis reveals distortions in the helical structure of the δM4 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor.Tryptophan-scanning mutagenesis in the alphaM3 transmembrane domain of the muscle-type acetylcholine receptor. A spring model revealed.Functional and structural identification of amino acid residues of the P2X2 receptor channel critical for the voltage- and [ATP]-dependent gating.Structural changes in the mitochondrial Tim23 channel are coupled to the proton-motive force.Contribution of conserved glycine residues to ATP action at human P2X1 receptors: mutagenesis indicates that the glycine at position 250 is important for channel function.
P2860
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P2860
Secondary structure and gating rearrangements of transmembrane segments in rat P2X4 receptor channels.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Secondary structure and gating ...... in rat P2X4 receptor channels.
@ast
Secondary structure and gating ...... in rat P2X4 receptor channels.
@en
type
label
Secondary structure and gating ...... in rat P2X4 receptor channels.
@ast
Secondary structure and gating ...... in rat P2X4 receptor channels.
@en
prefLabel
Secondary structure and gating ...... in rat P2X4 receptor channels.
@ast
Secondary structure and gating ...... in rat P2X4 receptor channels.
@en
P2093
P2860
P356
P1476
Secondary structure and gating ...... in rat P2X4 receptor channels.
@en
P2093
Kenton J Swartz
Shai D Silberberg
Tsg-Hui Chang
P2860
P304
P356
10.1085/JGP.200409221
P577
2005-04-01T00:00:00Z