Pore-opening mechanism in trimeric P2X receptor channels
about
Molecular and functional properties of P2X receptors--recent progress and persisting challengesIon access pathway to the transmembrane pore in P2X receptor channelsInsights into the channel gating of P2X receptors from structures, dynamics and small moleculesStructure and activity of the acid-sensing ion channelsSize matters in activation/inhibition of ligand-gated ion channelsPrinciples and properties of ion flow in P2X receptorsInsights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide PolymorphismsMolecular mechanism of ATP binding and ion channel activation in P2X receptorsX-ray structures define human P2X3 receptor gating cycle and antagonist actionA dual polybasic motif determines phosphoinositide binding and regulation in the P2X channel familyPhysical basis of apparent pore dilation of ATP-activated P2X receptor channelsConductance of P2X4 purinergic receptor is determined by conformational equilibrium in the transmembrane regionLocalization of the gate and selectivity filter of the full-length P2X7 receptorMechanisms of ATP release and signalling in the blood vessel wall.Tightening of the ATP-binding sites induces the opening of P2X receptor channelsSignal transmission within the P2X2 trimeric receptor.Neuromodulation by extracellular ATP and P2X receptors in the CNS.General rules for the arrangements and gating motions of pore-lining helices in homomeric ion channels.Non-synonymous single nucleotide polymorphisms in the P2X receptor genes: association with diseases, impact on receptor functions and potential use as diagnosis biomarkersPosition and motions of the S4 helix during opening of the Shaker potassium channel.The second transmembrane domain of P2X7 contributes to dilated pore formationFunctional identification of close proximity amino acid side chains within the transmembrane-spanning helixes of the P2X2 receptorAgonist trapped in ATP-binding sites of the P2X2 receptor.Activation and regulation of purinergic P2X receptor channelsStructural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7).Gating mechanism of a P2X4 receptor developed from normal mode analysis and molecular dynamics simulationsPhoto-switchable tweezers illuminate pore-opening motions of an ATP-gated P2X ion channelSubtype-specific control of P2X receptor channel signaling by ATP and Mg2+.Inter- and intrasubunit interactions between transmembrane helices in the open state of P2X receptor channels.Emerging approaches to probing ion channel structure and function.Post-translational regulation of P2X receptor channels: modulation by phospholipidsKey sites for P2X receptor function and multimerization: overview of mutagenesis studies on a structural basis.Ectodomain movements of an ATP-gated ion channel (P2X2 receptor) probed by disulfide locking.Highly conserved tyrosine 37 stabilizes desensitized states and restricts calcium permeability of ATP-gated P2X3 receptor.The intracellular amino terminus plays a dominant role in desensitization of ATP-gated P2X receptor ion channels.Metal bridges illuminate transmembrane domain movements during gating of the cystic fibrosis transmembrane conductance regulator chloride channel.Direct gating of ATP-activated ion channels (P2X2 receptors) by lipophilic attachment at the outer end of the second transmembrane domainSTIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate.The pain receptor TRPV1 displays agonist-dependent activation stoichiometry.Intermediate closed channel state(s) precede(s) activation in the ATP-gated P2X2 receptor.
P2860
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P2860
Pore-opening mechanism in trimeric P2X receptor channels
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Pore-opening mechanism in trimeric P2X receptor channels
@ast
Pore-opening mechanism in trimeric P2X receptor channels
@en
Pore-opening mechanism in trimeric P2X receptor channels
@nl
type
label
Pore-opening mechanism in trimeric P2X receptor channels
@ast
Pore-opening mechanism in trimeric P2X receptor channels
@en
Pore-opening mechanism in trimeric P2X receptor channels
@nl
prefLabel
Pore-opening mechanism in trimeric P2X receptor channels
@ast
Pore-opening mechanism in trimeric P2X receptor channels
@en
Pore-opening mechanism in trimeric P2X receptor channels
@nl
P2093
P2860
P356
P1476
Pore-opening mechanism in trimeric P2X receptor channels
@en
P2093
Kenton J Swartz
Shai D Silberberg
Toshimitsu Kawate
P2860
P2888
P356
10.1038/NCOMMS1048
P407
P577
2010-07-27T00:00:00Z
P5875
P6179
1007451590