BRD4 is a novel therapeutic target for liver fibrosis. - Wikidata - awgldk - TriplyDB

BRD4 is a novel therapeutic target for liver fibrosis.

BRD4 is a novel therapeutic target for liver fibrosis.

http://www.wikidata.org/entity/Q36419888

about

Targeting Mechanotransduction at the Transcriptional Level: YAP and BRD4 Are Novel Therapeutic Targets for the Reversal of Liver Fibrosis Drug Discovery Targeting Bromodomain-Containing Protein 4.ETS-targeted therapy: can it substitute for MEK inhibitors?The Soft- and Hard-Heartedness of Cardiac Fibroblasts: Mechanotransduction Signaling Pathways in Fibrosis of the Heart.Novel insights into a reputably irreversible process: combined mRNA and miRNA profiling of tissue from vesicourethral anastomotic stenosis after radical prostatectomy.Pyruvate dehydrogenase kinase regulates hepatitis C virus replication.High fat diet-induced changes of mouse hepatic transcription and enhancer activity can be reversed by subsequent weight loss.BET inhibitors block pancreatic stellate cell collagen I production and attenuate fibrosis in vivo.Pharmacological targeting of BET proteins inhibits renal fibroblast activation and alleviates renal fibrosis Targeting Transcriptional and Epigenetic Reprogramming in Stromal Cells in Fibrosis and Cancer.Epigenetic regulation of cardiac fibrosis.BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance.Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation.BRD4 mediates NF-κB-dependent epithelial-mesenchymal transition and pulmonary fibrosis via transcriptional elongation.Epigenetics and Liver Fibrosis.BRD4 inhibition for the treatment of pathological organ fibrosis Hepatic stellate cells as key target in liver fibrosis.BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure.Stromal remodeling by the BET bromodomain inhibitor JQ1 suppresses the progression of human pancreatic cancer.Convergent roles of ATF3 and CSL in chromatin control of cancer-associated fibroblast activation.BRD4 inhibitors block telomere elongation.Epigenetic reprogramming in liver fibrosis and cancer.Pharmacological targeting of BET proteins attenuates radiation-induced lung fibrosis.Biology and Mechanisms of Action of the Vitamin D Hormone.RNAi screening identifies a mechanosensitive ROCK-JAK2-STAT3 network central to myofibroblast activation.Benefit of Apabetalone on Plasma Proteins in Renal Disease.Epigenetic Regulation of Myofibroblast Phenotypes in Fibrosis CXCL6-EGFR-induced Kupffer cells secrete TGF-β1 promoting hepatic stellate cell activation via the SMAD2/BRD4/C-MYC/EZH2 pathway in liver fibrosis Epigenetics in Cardiac Fibrosis: Emphasis on Inflammation and Fibroblast Activation

P2860

Q28070012-51C5A77C-871E-4BE6-955E-E10B7EA5F92B Q30352390-3B3FFAFE-454D-425C-82D4-9B48743DF86E Q33638827-17E57942-1280-4338-8EF4-856341E8F0D7 Q33737254-F15C996B-4830-4269-B86C-E6198A1224C9 Q36410973-108D4ADB-C526-4F45-B1AD-20412FB704E5 Q37137222-D673B009-F20B-42D8-8131-924656416CE6 Q37575928-0DAA548E-1DE4-4425-9CFA-16F068D391AC Q37624355-5ECA0233-B850-4651-9226-881549AA5854 Q37688355-C1BC6130-96E1-439B-90AA-B0568263D73E Q38708376-79BA0613-7DCA-4C9C-BCEB-C4AD44806D89 Q38733315-0AA671A8-A5F7-4C58-BFBD-8D7F721AA6C0 Q38776637-E91D725D-2164-4B93-95DC-7A70DD6C53C1 Q38970003-1A923A5B-CFF1-4C54-B327-7B388E6884B4 Q39236663-0535CE50-A9C7-4E70-8F67-91DAF99FCC5F Q39358760-37A13F1B-9213-4636-A4AC-B2457B92C12F Q39442981-3DB667C5-7C85-42C3-AFF1-A79DCE2C761A Q40200602-5F39174E-80BC-41E6-8471-D59FA5410057 Q41255959-4AB469F8-6742-47F7-A92C-2F8A60415B44 Q42321605-8EBF0797-9667-48AB-8B01-36F54D418741 Q42512025-9DE0C618-34C9-4740-9E8E-8F0F7651EEF4 Q47136781-65DC80DF-F665-4FE5-934A-B2EA9044370B Q47157566-9F93B005-2AE1-4147-9E03-ACB8B59CE581 Q48223411-A9E9FA66-2B32-44FC-BCF5-930960561AF7 Q50101275-63BA9E52-74C1-4C8A-BFCC-8AD481F68402 Q52573450-7F8EAA54-2D2D-4265-A075-06DA1893834E Q55316265-D5A8628B-37B5-4916-9DEB-036BCF8C8E58 Q57147732-07BB8A93-DFB1-4825-B9C5-E73E2CC166FD Q58779664-8FA54CA8-9F2E-4CCD-9787-96A64B5B26C9 Q59136748-E012E380-B6CC-4FB5-B1C7-B5BD9736D95F

P2860

BRD4 is a novel therapeutic target for liver fibrosis.

http://www.wikidata.org/entity/Q36419888

description

2015 nî lūn-bûn

@nan

2015年の論文

@ja

2015年学术文章

@wuu

2015年学术文章

@zh-cn

2015年学术文章

@zh-hans

2015年学术文章

@zh-my

2015年学术文章

@zh-sg

2015年學術文章

@yue

2015年學術文章

@zh

2015年學術文章

@zh-hant

name

BRD4 is a novel therapeutic target for liver fibrosis.

@ast

BRD4 is a novel therapeutic target for liver fibrosis.

@en

type

label

BRD4 is a novel therapeutic target for liver fibrosis.

@ast

BRD4 is a novel therapeutic target for liver fibrosis.

@en

prefLabel

BRD4 is a novel therapeutic target for liver fibrosis.

@ast

BRD4 is a novel therapeutic target for liver fibrosis.

@en

P1433

Q36419888-7E7DCE91-401B-42C7-82EE-0FDCB31A3F6A

P1476

Q36419888-EC3D492B-4016-47F4-8823-6E8C5E2D0000

P2093

Q36419888-4EAA38F8-C6BB-4315-B3E5-6EE09107DCC5

Q36419888-55B29962-EE90-4D48-B598-F2B1DB2B7615

Q36419888-58B0731B-3761-4A81-889F-6A6EDA38C81F

Q36419888-D6BDD374-EDE3-4981-84C7-210DEAF2C7C1

Q36419888-E28377D6-D8A6-4268-A46E-70FE90E3DCA3

Q36419888-F178008A-8DF3-47B8-B713-8E254186115E

Q36419888-F6C046FF-BDB0-4C87-8F74-41D8DB8C61FE

Q36419888-F9E72AC8-4E03-4D1C-B16B-71B057B9E5E8

P2860

Q36419888-07F9712E-AB94-4AAC-AA22-53D1DD21ECB5

Q36419888-082A4A9C-F0F1-4DB4-8BF0-25A1F2828C49

Q36419888-137E540E-322D-4085-80EB-050A7DFC7BAC

Q36419888-2160EE3D-1CB2-464D-9A9B-60A79AB913CD

Q36419888-2A65DD48-570A-4D6C-872F-BA35294B3D7E

Q36419888-3E2AB91E-CC4F-4F3D-96EA-59E3C1FAA5FE

Q36419888-4B659795-6116-4BFA-BE6F-D85888BEC0EC

Q36419888-6E2DE9F8-49DA-4B3F-B564-587ADC484527

Q36419888-7240ED29-40B8-46E8-8679-00E0F5C52C31

Q36419888-98D24EDF-73EC-4F80-89BA-0FD479C041E5

P304

Q36419888-09CB2201-D034-47B3-A3B7-8648A1076CB5

P31

Q36419888-7D5AD199-8935-40BC-A7C2-78787B57646C

P356

Q36419888-EE04B168-C4A1-4DAF-A498-84F912F7A4DB

P407

Q36419888-E87D92DF-FA4D-4F00-94DB-9409571F8588

P433

Q36419888-C7E3677A-E1D6-4EBE-AA38-6BAC545D8D30

P478

Q36419888-95C66F9C-EF5D-4C0E-8199-15771CE29891

P50

Q36419888-10890711-16DA-4B66-BB67-42F91C8654C6

Q36419888-3D5CB33E-9FD7-4025-9CD3-26398E16A93D

P577

Q36419888-6EDF2C4C-2559-4754-8CB4-CD3518140F25

P698

Q36419888-75A0EAB7-D02B-449D-8BBB-CC92430A1CC8

P932

Q36419888-A0F86E0D-D2D6-4A61-B89A-D7F68B82BB7D

P356

PNAS.1522163112

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

BRD4 is a novel therapeutic target for liver fibrosis.

@en

P2093

Christopher Liddle

http://www.w3.org/2001/XMLSchema#string

Mara H Sherman

http://www.w3.org/2001/XMLSchema#string

Mathias Leblanc

http://www.w3.org/2001/XMLSchema#string

Michael Downes

http://www.w3.org/2001/XMLSchema#string

Mingxiao He

http://www.w3.org/2001/XMLSchema#string

Nasun Hah

http://www.w3.org/2001/XMLSchema#string

Ning Ding

http://www.w3.org/2001/XMLSchema#string

Ruth T Yu

http://www.w3.org/2001/XMLSchema#string

P2860

Selective inhibition of BET bromodomains

Cellular and molecular mechanisms of fibrosis

Suppression of inflammation by a synthetic histone mimic

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit

Differential analysis of gene regulation at transcript resolution with RNA-seq

STAR: ultrafast universal RNA-seq aligner

Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver

TLR4 enhances TGF-beta signaling and hepatic fibrosis

P304

15713-15718

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.1522163112

http://www.w3.org/2001/XMLSchema#string

P407

P433

51

http://www.w3.org/2001/XMLSchema#string

P478

112

http://www.w3.org/2001/XMLSchema#string

P50

Ronald M. Evans

P577

2015-12-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

26644586

http://www.w3.org/2001/XMLSchema#string

P932

4697417

http://www.w3.org/2001/XMLSchema#string