A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2
about
Minimotif Miner 3.0: database expansion and significantly improved reduction of false-positive predictions from consensus sequencesRemodeling of the Host Cell Plasma Membrane by HIV-1 Nef and Vpu: A Strategy to Ensure Viral Fitness and PersistenceConformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assemblyHow HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4Counteraction of the multifunctional restriction factor tetherinHIV-1 nef protein structures associated with brain infection and dementia pathogenesisHIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells.A screen for endocytic motifs.SIV Nef proteins recruit the AP-2 complex to antagonize Tetherin and facilitate virion release.Conservation and diversification of dileucine signal recognition by adaptor protein (AP) complex variantsSelf-association of the Lentivirus protein, NefA cytoplasmic tail determinant in HIV-1 Vpu mediates targeting of tetherin for endosomal degradation and counteracts interferon-induced restriction.Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor.Cargo recognition in clathrin-mediated endocytosisTrans-cellular introduction of HIV-1 protein Nef induces pathogenic response in Caenorhabditis elegans.Tetherin/BST-2 antagonism by Nef depends on a direct physical interaction between Nef and tetherin, and on clathrin-mediated endocytosis.At the crossroads of homoeostasis and disease: roles of the PACS proteins in membrane traffic and apoptosis.Misdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence.Adaptor protein complex-2 (AP-2) and epsin-1 mediate protease-activated receptor-1 internalization via phosphorylation- and ubiquitination-dependent sorting signals.Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.HIV-1 Env and Nef Cooperatively Contribute to Plasmacytoid Dendritic Cell Activation via CD4-Dependent MechanismsThe apoptotic engulfment protein Ced-6 participates in clathrin-mediated yolk uptake in Drosophila egg chambers.The Continuing Evolution of HIV-1 Therapy: Identification and Development of Novel Antiretroviral Agents Targeting Viral and Cellular Targets.Nef promotes evasion of human immunodeficiency virus type 1-infected cells from the CTLA-4-mediated inhibition of T-cell activation.Human leukocyte antigen (HLA) class I down-regulation by human immunodeficiency virus type 1 negative factor (HIV-1 Nef): what might we learn from natural sequence variants?Competition model for upregulation of the major histocompatibility complex class II-associated invariant chain by human immunodeficiency virus type 1 NefDown-modulation of primate lentiviral receptors by Nef proteins of simian immunodeficiency virus (SIV) of chimpanzees (SIVcpz) and related SIVs: implication for the evolutionary event at the emergence of SIVcpz.HIV-1 Nef: at the crossroadsActivity-Regulated Cytoskeleton-Associated Protein Controls AMPAR Endocytosis through a Direct Interaction with Clathrin-Adaptor Protein 2.A basic patch on alpha-adaptin is required for binding of human immunodeficiency virus type 1 Nef and cooperative assembly of a CD4-Nef-AP-2 complex.Mechanisms of HIV-1 Nef function and intracellular signaling.Human immunodeficiency virus type 1 Nef protein targets CD4 to the multivesicular body pathway.The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor.HIV-1 Nef down-modulates C-C and C-X-C chemokine receptors via ubiquitin and ubiquitin-independent mechanismHIV immune evasion disruption of antigen presentation by the HIV Nef protein.Cell-based Fluorescence Complementation Reveals a Role for HIV-1 Nef Protein Dimerization in AP-2 Adaptor Recruitment and CD4 Co-receptor Down-regulation.Amino acids at positions 3, 168, and 169 are associated with the ability of Nef proteins from HIV-1 CRF01_AE to downmodulate CD4.HIV-1 Nef: Taking Control of Protein Trafficking.HIV-1 Nef promotes the localization of Gag to the cell membrane and facilitates viral cell-to-cell transfer.Proteomic analysis of HIV-1 Nef cellular binding partners reveals a role for exocyst complex proteins in mediating enhancement of intercellular nanotube formation.
P2860
Q24620727-7955590D-9908-4B86-B460-DC7FD244852BQ26767362-6603CBAA-6B82-4853-871D-7F894D9F6D38Q27667185-47653F0D-73A6-40A9-9BC7-20B54DC722FCQ27681494-65DC46C5-95A6-4BD8-AA0B-B72A2A1A18D7Q28659945-7FFAB77F-3068-475E-ADC4-4DB6C1C530E9Q28742931-FE267407-58BA-4BA6-8E8A-0999EC71A9BCQ33363091-2B596B7F-5838-4F3C-8629-2A0B09BD188CQ33538857-CE59154C-6F08-45BD-BF12-7CC07A52A93EQ33916620-554A0E0C-523B-4720-A879-4137DB7C7500Q34151231-2F161D7F-3C52-41B2-924E-2C7B19F28420Q34203170-8D0904B1-A064-478C-A591-A1CCB588D8D4Q34220959-7DFE6DB9-6F7A-46E3-A66C-068CE2F4B222Q34283497-19224F98-7859-4634-9662-E4CAA6AC3E56Q34382206-2775401C-C51D-4EFA-A985-5176BDEB4E0AQ34403732-E4F6DB0F-476E-467A-A63B-06EA82EFB855Q34819697-8D398710-9B29-49C6-8C98-D8B8028E7ED7Q34999872-CF7168C6-6B5D-440F-A082-93C74285038EQ35214569-0E03BAC4-CB79-4DED-BD7C-AFDBD5DDA882Q35562523-EDA29457-FC2D-47C7-8631-4ADCCB0FAF85Q35665886-ACF32DFE-4538-4813-A6D2-5DBAE53F27E7Q35861175-BFB91B72-2D86-4F50-9384-CF6A0FB2F9DBQ35917935-87E65E13-1CE3-4C1E-841C-AECDC5333837Q36104509-B2BF0288-E3E3-41EE-8D02-6DC74F0E464BQ36255107-75101B0D-F496-41D6-AB17-77C8FD1E6BE8Q36404189-54064BCD-A94B-439F-8412-5E0FD79F8919Q36845640-DBF5FBE2-66A4-4AD6-9362-45F068B94164Q36871889-0EA7BD1B-3C78-48FE-AC5F-3DF98CE2FACDQ36926697-4E86880A-C553-457E-847F-9996D9697820Q36928756-D8F33786-505F-4C89-B061-D335CFA65134Q37110624-ABC6B8F0-6663-469D-BED3-11AB03C74B6FQ37183848-864494C6-38BE-45D8-AA5E-5CB7BFBAE5EBQ37232786-3BCD88FF-AF05-4D12-883B-E1F33BD5016BQ37415400-02B2F764-C1ED-4C56-99F1-7523D383BAE9Q37529530-3E9010B8-A918-4FEF-A663-2DF7CB00CA69Q37901625-A07E13D4-DDCC-42A7-80AE-E53D0C2C8898Q38723908-3D00E1F8-B39A-4B5B-870A-E77035861BD3Q38788293-5454A7C6-BCDA-4832-AD31-D65D9D7E9D4AQ38830464-554DBC88-669E-4B23-AEAC-76682F38C648Q39118089-0CE0D8C9-0586-479C-8B18-DFE61C08E692Q39358737-7A3988CE-BA58-47AC-A7EB-268BE49F027C
P2860
A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
A diacidic motif in human immu ...... determinant of binding to AP-2
@ast
A diacidic motif in human immu ...... determinant of binding to AP-2
@en
type
label
A diacidic motif in human immu ...... determinant of binding to AP-2
@ast
A diacidic motif in human immu ...... determinant of binding to AP-2
@en
prefLabel
A diacidic motif in human immu ...... determinant of binding to AP-2
@ast
A diacidic motif in human immu ...... determinant of binding to AP-2
@en
P2093
P2860
P356
P1433
P1476
A diacidic motif in human immu ...... determinant of binding to AP-2
@en
P2093
James H Hurley
O Wolf Lindwasser
Peter Yang
Rittik Chaudhuri
William J Smith
P2860
P304
P356
10.1128/JVI.01874-07
P407
P577
2007-11-21T00:00:00Z