HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways - Wikidata - awgldk - TriplyDB

HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways

HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways

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Highlights on distinctive structural and functional properties of HTLV Tax proteins Molecular Mechanisms of HTLV-1 Cell-to-Cell Transmission Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis Activation of the DNA Damage Response by RNA Viruses Novel interactions between the HTLV antisense proteins HBZ and APH-2 and the NFAR protein family: Implications for the HTLV lifecycles HTLV-1 Tax Functions as a Ubiquitin E3 Ligase for Direct IKK Activation via Synthesis of Mixed-Linkage Polyubiquitin Chains Exosomes in Viral Disease.Epigenetic modification of the FoxP3 TSDR in HAM/TSP decreases the functional suppression of Tregs.Viruses and human cancers: a long road of discovery of molecular paradigms.Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain Tax protein.A non-SUMOylated tax protein is still functional for NF-κB pathway activation.Acetylation of the c-MYC oncoprotein is required for cooperation with the HTLV-1 p30(II) accessory protein and the induction of oncogenic cellular transformation by p30(II)/c-MYC.Gem-induced cytoskeleton remodeling increases cellular migration of HTLV-1-infected cells, formation of infected-to-target T-cell conjugates and viral transmission.Human T-cell leukemia virus type 1 (HTLV-1) tax requires CADM1/TSLC1 for inactivation of the NF-κB inhibitor A20 and constitutive NF-κB signaling.Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB STAT1: A Novel Target of miR-150 and miR-223 Is Involved in the Proliferation of HTLV-I-Transformed and ATL Cells.Identification of novel monocistronic HTLV-1 mRNAs encoding functional Rex isoforms.Inducible nitric oxide synthase mediates DNA double strand breaks in Human T-Cell Leukemia Virus Type 1-induced leukemia/lymphoma.Multiple Pathways Control the Reactivation of Telomerase in HTLV-I-Associated Leukemia.The Tax-Inducible Actin-Bundling Protein Fascin Is Crucial for Release and Cell-to-Cell Transmission of Human T-Cell Leukemia Virus Type 1 (HTLV-1).HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains.Retargeting Oncolytic Vesicular Stomatitis Virus to Human T-Cell Lymphotropic Virus Type 1-Associated Adult T-Cell Leukemia Akt Pathway Activation by Human T-cell Leukemia Virus Type 1 Tax Oncoprotein.Discovery of an endogenous Deltaretrovirus in the genome of long-fingered bats (Chiroptera: Miniopteridae).Role of WWOX and NF-κB in lung cancer progression Cellular Immune Responses against Simian T-Lymphotropic Virus Type 1 Target Tax in Infected Baboons.Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol.HSP90 protects the human T-cell leukemia virus type 1 (HTLV-1) tax oncoprotein from proteasomal degradation to support NF-κB activation and HTLV-1 replication WRN-targeted therapy using inhibitors NSC 19630 and NSC 617145 induce apoptosis in HTLV-1-transformed adult T-cell leukemia cells.Comparison of HTLV-I Proviral Load in Adult T Cell Leukemia/Lymphoma (ATL), HTLV-I-Associated Myelopathy (HAM-TSP) and Healthy Carriers.Doxycycline is an NF-κB inhibitor that induces apoptotic cell death in malignant T-cells.Niclosamide, an anti-helminthic molecule, downregulates the retroviral oncoprotein Tax and pro-survival Bcl-2 proteins in HTLV-1-transformed T lymphocytes.Expression and significance of Pim-3 kinase in adult T-cell leukemia.Adult T cell leukemia aggressivenness correlates with loss of both 5-hydroxymethylcytosine and TET2 expression.Hijacking of the O-GlcNAcZYME complex by the HTLV-1 Tax oncoprotein facilitates viral transcription.Induction of the pro-inflammatory NF-kB-sensitive miRNA-146a by human neurotrophic viruses.A transgenic mouse model of human T cell leukemia virus type 1-associated diseases.Forefront studies on HTLV-1 oncogenesis.Interference of HTLV-1 Tax Protein with Cell Polarity Regulators: Defining the Subcellular Localization of the Tax-DLG1 Interaction.HTLV-1, the Other Pathogenic Yet Neglected Human Retrovirus: From Transmission to Therapeutic Treatment.

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HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways

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2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways

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HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways

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HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways

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HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways

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HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways

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HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways

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Frontiers in Microbiology

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HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways

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Aarthi Narayanan

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Elizabeth Jaworski

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Fatah Kashanchi

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Gavin Sampey

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Irene Guendel

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Rachel Van Duyne

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Robert Currer

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P2860

The HTLV-1 Tax interactome

HTLV-1 Tax mediated downregulation of miRNAs associated with chromatin remodeling factors in T cells with stably integrated viral promoter

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK

Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein

The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins

The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling

Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1

Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling

Human T-cell lymphotropic virus type 1-infected T lymphocytes impair catabolism and uptake of glutamate by astrocytes via Tax-1 and tumor necrosis factor alpha

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3

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